146446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2476337..2476859 Replicon chromosome
Accession NZ_CP047531
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10484

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN09_RS12140 Protein ID WP_000221343.1
Coordinates 2476575..2476859 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN09_RS12135 Protein ID WP_000885424.1
Coordinates 2476337..2476585 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN09_RS12110 (2471553) 2471553..2473019 + 1467 WP_000987828.1 hypothetical protein -
DXN09_RS12115 (2473827) 2473827..2474541 + 715 Protein_2377 helix-turn-helix domain-containing protein -
DXN09_RS12120 (2474597) 2474597..2475505 - 909 WP_010989018.1 hypothetical protein -
DXN09_RS12125 (2475648) 2475648..2475980 - 333 WP_000253154.1 DUF1493 family protein -
DXN09_RS12130 (2475970) 2475970..2476185 - 216 WP_000206207.1 hypothetical protein -
DXN09_RS12135 (2476337) 2476337..2476585 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN09_RS12140 (2476575) 2476575..2476859 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN09_RS12145 (2477030) 2477030..2477419 + 390 WP_000194089.1 RidA family protein -
DXN09_RS12150 (2477471) 2477471..2478550 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN09_RS12155 (2478743) 2478743..2479231 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN09_RS12160 (2479276) 2479276..2480784 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2471556..2483641 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146446 WP_000221343.1 NZ_CP047531:2476575-2476859 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146446 NZ_CP062749:c5056450-5056277 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146446 WP_000885424.1 NZ_CP047531:2476337-2476585 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146446 NZ_CP062749:c5056774-5056478 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References