Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 195934..196688 Replicon chromosome
Accession NZ_CP047529
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag DXN10_RS00975 Protein ID WP_000558166.1
Coordinates 196377..196688 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DXN10_RS00970 Protein ID WP_001259011.1
Coordinates 195934..196380 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN10_RS00940 (191110) 191110..192006 + 897 WP_001520529.1 sugar kinase -
DXN10_RS00945 (192040) 192040..192843 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
DXN10_RS00950 (193034) 193034..193633 + 600 WP_000965695.1 glucose-1-phosphatase -
DXN10_RS00955 (193627) 193627..194499 + 873 WP_000921427.1 virulence factor BrkB family protein -
DXN10_RS00960 (194496) 194496..194933 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
DXN10_RS00965 (194978) 194978..195919 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
DXN10_RS00970 (195934) 195934..196380 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
DXN10_RS00975 (196377) 196377..196688 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
DXN10_RS00980 (196774) 196774..197703 - 930 WP_001127703.1 alpha/beta hydrolase -
DXN10_RS00985 (197921) 197921..198232 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
DXN10_RS00990 (198233) 198233..198523 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
DXN10_RS00995 (198570) 198570..199499 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
DXN10_RS01000 (199496) 199496..200131 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
DXN10_RS01005 (200128) 200128..201030 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T146407 WP_000558166.1 NZ_CP047529:c196688-196377 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T146407 NZ_CP062746:c3571494-3571339 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT146407 WP_001259011.1 NZ_CP047529:c196380-195934 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT146407 NZ_CP062746:3571506-3571564 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References