Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 197921..198523 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag DXN11_RS00985 Protein ID WP_001159630.1
Coordinates 197921..198232 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DXN11_RS00990 Protein ID WP_000362050.1
Coordinates 198233..198523 (+) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS00950 (193034) 193034..193633 + 600 WP_000965695.1 glucose-1-phosphatase -
DXN11_RS00955 (193627) 193627..194499 + 873 WP_000921427.1 virulence factor BrkB family protein -
DXN11_RS00960 (194496) 194496..194933 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
DXN11_RS00965 (194978) 194978..195919 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
DXN11_RS00970 (195934) 195934..196380 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
DXN11_RS00975 (196377) 196377..196688 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
DXN11_RS00980 (196774) 196774..197703 - 930 WP_001127703.1 alpha/beta hydrolase -
DXN11_RS00985 (197921) 197921..198232 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
DXN11_RS00990 (198233) 198233..198523 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
DXN11_RS00995 (198570) 198570..199499 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
DXN11_RS01000 (199496) 199496..200131 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
DXN11_RS01005 (200128) 200128..201030 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T146383 WP_001159630.1 NZ_CP047527:197921-198232 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T146383 NZ_CP062744:4477503-4477763 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT146383 WP_000362050.1 NZ_CP047527:198233-198523 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT146383 NZ_CP062744:4477224-4477484 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64


Antitoxin

Source ID Structure

References