Detailed information of TA system TA146353

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 54174..54438
• Replicon: plasmid unnamedB
• Accession: NZ_CP047524
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: DXN15_RS25435
• Protein ID: WP_001387489.1
• Coordinates: 54286..54438 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	54174..54234 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN15_RS25420 (50276)	50276..51346	-	1071	WP_012783932.1	IncI1-type conjugal transfer protein TrbB	-
DXN15_RS25425 (51365)	51365..52573	-	1209	WP_001703845.1	IncI1-type conjugal transfer protein TrbA	-
DXN15_RS25430 (52880)	52880..53659	-	780	WP_275450201.1	protein FinQ	-
- (54174)	54174..54234	-	61	NuclAT_0	-	Antitoxin
- (54174)	54174..54234	-	61	NuclAT_0	-	Antitoxin
- (54174)	54174..54234	-	61	NuclAT_0	-	Antitoxin
- (54174)	54174..54234	-	61	NuclAT_0	-	Antitoxin
DXN15_RS25435 (54286)	54286..54438	+	153	WP_001387489.1	Hok/Gef family protein	Toxin
DXN15_RS25440 (54510)	54510..54761	-	252	WP_001291964.1	hypothetical protein	-
DXN15_RS25670 (55262)	55262..55357	+	96	WP_000609148.1	DinQ-like type I toxin DqlB	-
DXN15_RS25450 (55422)	55422..55598	-	177	WP_001054900.1	hypothetical protein	-
DXN15_RS25455 (55990)	55990..56199	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
DXN15_RS25460 (56271)	56271..56933	-	663	WP_012783935.1	plasmid IncI1-type surface exclusion protein ExcA	-
DXN15_RS25465 (57004)	57004..59172	-	2169	WP_015508354.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-14	-	1..87292	87292

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T146353 WP_001387489.1 NZ_CP047524:54286-54438 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T146353 NZ_CP062742:c4471566-4471168 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT146353 NZ_CP047524:c54234-54174 [Salmonella enterica subsp. enterica serovar Typhimurium]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin