Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4703308..4703968 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GT391_RS21105 Protein ID WP_010284411.1
Coordinates 4703615..4703968 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GT391_RS21100 Protein ID WP_010284412.1
Coordinates 4703308..4703610 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS21065 4698453..4698908 - 456 WP_039320430.1 helix-turn-helix domain-containing protein -
GT391_RS21070 4698975..4700210 + 1236 WP_010284426.1 MFS transporter -
GT391_RS21075 4700260..4700895 - 636 WP_010284424.1 NAD(P)H-binding protein -
GT391_RS21080 4700952..4701377 - 426 WP_010284422.1 DoxX family protein -
GT391_RS21085 4701455..4701859 + 405 WP_199559763.1 helix-turn-helix transcriptional regulator -
GT391_RS21090 4701875..4702213 - 339 WP_010284418.1 helix-turn-helix domain-containing protein -
GT391_RS21095 4702266..4703270 + 1005 WP_010284416.1 threonine/serine dehydratase -
GT391_RS21100 4703308..4703610 - 303 WP_010284412.1 helix-turn-helix domain-containing protein Antitoxin
GT391_RS21105 4703615..4703968 - 354 WP_010284411.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GT391_RS21110 4704406..4705245 + 840 WP_010284408.1 glutathione-dependent disulfide-bond oxidoreductase -
GT391_RS21115 4705305..4706549 - 1245 WP_010284407.1 multidrug effflux MFS transporter -
GT391_RS21120 4706643..4707929 + 1287 WP_039320386.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13475.49 Da        Isoelectric Point: 9.8932

>T146326 WP_010284411.1 NZ_CP047495:c4703968-4703615 [Pectobacterium brasiliense]
VWKIETTDVFDSWFSTLNDRDRAYVLAALIVLREKGPMLSRPYADTVKGSRYSNMKELRIQSGGMPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMIPLADREFTTYLKKSEKKG

Download         Length: 354 bp

>T146326 NZ_CP062739:5035860-5036201 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11107.90 Da        Isoelectric Point: 6.2283

>AT146326 WP_010284412.1 NZ_CP047495:c4703610-4703308 [Pectobacterium brasiliense]
MGRTLEQLLADEKPDVVVEAHAIAADMLLNIHLAELRERVQKTQVEMAQVLGLKQPTIAGMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYGFTL

Download         Length: 303 bp

>AT146326 NZ_CP062739:c5035865-5035789 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References