Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4839628..4840217 Replicon chromosome
Accession NZ_CP047493
Organism Xanthomonas oryzae pv. oryzae strain IXO792

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag IXO792_RS22665 Protein ID WP_012443754.1
Coordinates 4839936..4840217 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO792_RS22660 Protein ID WP_011260746.1
Coordinates 4839628..4839918 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO792_RS22630 (IXO792_22600) 4834913..4835389 - 477 WP_011260741.1 DUF4123 domain-containing protein -
IXO792_RS22635 (IXO792_22605) 4835392..4835805 - 414 WP_012443758.1 PAAR domain-containing protein -
IXO792_RS22640 (IXO792_22610) 4835942..4836268 - 327 WP_228329596.1 hypothetical protein -
IXO792_RS22645 (IXO792_22615) 4836523..4836855 + 333 WP_011260743.1 hypothetical protein -
IXO792_RS22650 4837015..4837202 + 188 Protein_4326 hypothetical protein -
IXO792_RS22655 (IXO792_22625) 4837305..4838699 - 1395 WP_011260745.1 type III secretion system effector XopQ -
IXO792_RS22660 (IXO792_22630) 4839628..4839918 - 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
IXO792_RS22665 (IXO792_22635) 4839936..4840217 - 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO792_RS22670 (IXO792_22640) 4840312..4842570 - 2259 WP_075240794.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T146311 WP_012443754.1 NZ_CP047493:c4840217-4839936 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T146311 NZ_CP062739:c2208381-2208274 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT146311 WP_011260746.1 NZ_CP047493:c4839918-4839628 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT146311 NZ_CP062739:2208434-2208495 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References