Detailed information of TA system TA146207

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2514049..2514776
• Replicon: chromosome
• Accession: NZ_CP047424
• Organism: Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8E5IJ81
• Locus tag: GTK42_RS12225
• Protein ID: WP_000558157.1
• Coordinates: 2514049..2514360 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GTK42_RS12230
• Protein ID: WP_000561389.1
• Coordinates: 2514357..2514776 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK42_RS12190 (2510326)	2510326..2510721	+	396	WP_000422887.1	DUF1398 domain-containing protein	-
GTK42_RS12195 (2511050)	2511050..2511526	+	477	WP_000030951.1	hypothetical protein	-
GTK42_RS12200 (2511636)	2511636..2511830	+	195	WP_001805175.1	hypothetical protein	-
GTK42_RS12205 (2511942)	2511942..2512400	-	459	WP_001195655.1	hypothetical protein	-
GTK42_RS12210 (2512671)	2512671..2513228	-	558	WP_000179886.1	hypothetical protein	-
GTK42_RS12215 (2513332)	2513332..2513541	-	210	WP_000754426.1	hypothetical protein	-
GTK42_RS12220 (2513571)	2513571..2513870	-	300	WP_000775226.1	hypothetical protein	-
GTK42_RS12225 (2514049)	2514049..2514360	+	312	WP_000558157.1	type II toxin-antitoxin system HigB family toxin	Toxin
GTK42_RS12230 (2514357)	2514357..2514776	+	420	WP_000561389.1	helix-turn-helix domain-containing protein	Antitoxin
GTK42_RS12235 (2515029)	2515029..2515682	+	654	Protein_2407	glycosyltransferase	-
GTK42_RS12240 (2515918)	2515918..2516337	-	420	WP_000354401.1	GNAT family N-acetyltransferase	-
GTK42_RS12245 (2516707)	2516707..2516973	+	267	WP_077906534.1	hypothetical protein	-
GTK42_RS12250 (2517142)	2517142..2517282	+	141	WP_001640444.1	hypothetical protein	-
GTK42_RS12255 (2517428)	2517428..2517969	-	542	Protein_2411	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2517428..2517766	338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12425.26 Da
• Isoelectric Point: 10.1376

>T146207 WP_000558157.1 NZ_CP047424:2514049-2514360 [Salmonella enterica subsp. enterica serovar Dessau]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE

Nucleotide

• Length: 312 bp

>T146207 NZ_CP062729:4820205-4820546 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15301.49 Da
• Isoelectric Point: 4.6286

>AT146207 WP_000561389.1 NZ_CP047424:2514357-2514776 [Salmonella enterica subsp. enterica serovar Dessau]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Nucleotide

• Length: 420 bp

>AT146207 NZ_CP062729:c4820210-4820134 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT