Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1319365..1319887 Replicon chromosome
Accession NZ_CP047363
Organism Macrococcus canis strain Epi0076A

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GTN30_RS06940 Protein ID WP_164953490.1
Coordinates 1319365..1319637 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GTN30_RS06945 Protein ID WP_164953491.1
Coordinates 1319630..1319887 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTN30_RS06910 1314443..1315690 + 1248 WP_138071149.1 putative DNA binding domain-containing protein -
GTN30_RS06915 1315735..1316181 - 447 WP_158290696.1 GNAT family N-acetyltransferase -
GTN30_RS06920 1316263..1317003 + 741 WP_164953486.1 hypothetical protein -
GTN30_RS06925 1317013..1317903 + 891 WP_164953487.1 phosphotransferase -
GTN30_RS06930 1318089..1318574 + 486 WP_164953488.1 NUDIX domain-containing protein -
GTN30_RS06935 1318580..1319347 + 768 WP_164953489.1 hypothetical protein -
GTN30_RS06940 1319365..1319637 - 273 WP_164953490.1 Txe/YoeB family addiction module toxin Toxin
GTN30_RS06945 1319630..1319887 - 258 WP_164953491.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTN30_RS06950 1320176..1320400 + 225 WP_138071164.1 toxin-antitoxin system, antitoxin component -
GTN30_RS06955 1320397..1320663 + 267 WP_138071166.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTN30_RS06960 1320766..1321260 + 495 WP_164953492.1 hypothetical protein -
GTN30_RS06965 1321421..1322638 + 1218 WP_164953493.1 ATP-binding protein -
GTN30_RS06970 1322774..1324036 + 1263 WP_164953494.1 Y-family DNA polymerase -
GTN30_RS06975 1324180..1324368 + 189 WP_164953495.1 hypothetical protein -
GTN30_RS06980 1324527..1324826 + 300 WP_096076536.1 DUF4298 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10698.44 Da        Isoelectric Point: 9.7524

>T146061 WP_164953490.1 NZ_CP047363:c1319637-1319365 [Macrococcus canis]
MTKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T146061 NZ_CP062719:4519471-4519731 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9787.83 Da        Isoelectric Point: 4.0808

>AT146061 WP_164953491.1 NZ_CP047363:c1319887-1319630 [Macrococcus canis]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLFQVE
IDLDD

Download         Length: 258 bp

>AT146061 NZ_CP062719:4519192-4519452 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References