146059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1159252..1159780 Replicon chromosome
Accession NZ_CP047361
Organism Macrococcus canis strain SD607

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GTN31_RS05840 Protein ID WP_164942130.1
Coordinates 1159252..1159530 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GTN31_RS05845 Protein ID WP_164942131.1
Coordinates 1159523..1159780 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTN31_RS05810 1154629..1155876 + 1248 WP_164942124.1 putative DNA binding domain-containing protein -
GTN31_RS05815 1155947..1156171 + 225 WP_164942125.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTN31_RS05820 1156236..1156682 - 447 WP_164942126.1 GNAT family N-acetyltransferase -
GTN31_RS05825 1156901..1157791 + 891 WP_164942127.1 phosphotransferase -
GTN31_RS05830 1157976..1158461 + 486 WP_164942128.1 NUDIX domain-containing protein -
GTN31_RS05835 1158467..1159207 + 741 WP_164942129.1 hypothetical protein -
GTN31_RS05840 1159252..1159530 - 279 WP_164942130.1 Txe/YoeB family addiction module toxin Toxin
GTN31_RS05845 1159523..1159780 - 258 WP_164942131.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTN31_RS05850 1160051..1160404 + 354 WP_164942132.1 GrpB family protein -
GTN31_RS05855 1160465..1160587 + 123 WP_164942133.1 GrpB family protein -
GTN31_RS05860 1160607..1161041 + 435 WP_164943016.1 GNAT family N-acetyltransferase -
GTN31_RS05865 1161043..1161243 + 201 WP_164942134.1 HAD family hydrolase -
GTN31_RS05870 1161407..1161874 + 468 WP_164942135.1 hypothetical protein -
GTN31_RS05875 1161971..1162339 + 369 WP_164942136.1 GntR family transcriptional regulator -
GTN31_RS05880 1162339..1163439 + 1101 WP_164942137.1 DUF1648 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10906.66 Da        Isoelectric Point: 9.5654

>T146059 WP_164942130.1 NZ_CP047361:c1159530-1159252 [Macrococcus canis]
MPKPKKEILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIDDDS
ICILQCRFHYKR

Download         Length: 279 bp

>T146059 NZ_CP062719:4255973-4256191 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9693.74 Da        Isoelectric Point: 4.1541

>AT146059 WP_164942131.1 NZ_CP047361:c1159780-1159523 [Macrococcus canis]
MKITSYSNARSNFRKIIDIVNEDSEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT146059 NZ_CP062719:4255573-4255947 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References