Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 710441..710954 Replicon chromosome
Accession NZ_CP047359
Organism Rickettsia japonica strain LA16/2015

Toxin (Protein)


Gene name yoeB Uniprot ID G4KME1
Locus tag GRX81_RS04090 Protein ID WP_014120591.1
Coordinates 710694..710954 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag GRX81_RS04085 Protein ID WP_014013992.1
Coordinates 710441..710683 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRX81_RS04065 705468..707237 - 1770 WP_024704469.1 ABC transporter ATP-binding protein/permease -
GRX81_RS04070 707418..707687 + 270 WP_014013989.1 DUF2671 domain-containing protein -
GRX81_RS04075 707842..709212 + 1371 WP_014120588.1 cytochrome ubiquinol oxidase subunit I -
GRX81_RS04080 709220..710239 + 1020 WP_014120589.1 cytochrome d ubiquinol oxidase subunit II -
GRX81_RS04085 710441..710683 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GRX81_RS04090 710694..710954 + 261 WP_014120591.1 Txe/YoeB family addiction module toxin Toxin
GRX81_RS04095 710947..711795 + 849 WP_014120592.1 glycosyltransferase family 2 protein -
GRX81_RS04100 711872..713110 + 1239 WP_014120593.1 insulinase family protein -
GRX81_RS04105 713264..713974 + 711 WP_014120594.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
GRX81_RS04110 714203..715789 + 1587 WP_014120595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10254.07 Da        Isoelectric Point: 9.8788

>T146041 WP_014120591.1 NZ_CP047359:710694-710954 [Rickettsia japonica]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVCEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

>T146041 NZ_CP062719:365362-365637 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT146041 WP_014013992.1 NZ_CP047359:710441-710683 [Rickettsia japonica]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp

>AT146041 NZ_CP062719:365634-365993 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3B7DC01

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References