Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3710138..3710640 Replicon chromosome
Accession NZ_CP047349
Organism Proteus terrae subsp. cibarius strain ZN2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GTH25_RS17000 Protein ID WP_075671248.1
Coordinates 3710386..3710640 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GTH25_RS16995 Protein ID WP_072068851.1
Coordinates 3710138..3710389 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH25_RS16970 3705731..3706507 + 777 WP_006534565.1 phosphate ABC transporter ATP-binding protein PstB -
GTH25_RS16975 3706522..3707256 + 735 WP_075671254.1 phosphate signaling complex protein PhoU -
GTH25_RS16980 3707472..3708311 + 840 WP_036933789.1 ABC transporter substrate-binding protein -
GTH25_RS16985 3708418..3709155 + 738 WP_075671252.1 amino acid ABC transporter permease -
GTH25_RS16990 3709157..3709909 + 753 WP_075671250.1 amino acid ABC transporter permease -
GTH25_RS16995 3710138..3710389 + 252 WP_072068851.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GTH25_RS17000 3710386..3710640 + 255 WP_075671248.1 Txe/YoeB family addiction module toxin Toxin
GTH25_RS17005 3710797..3712155 + 1359 WP_075671246.1 NCS2 family permease -
GTH25_RS17010 3712236..3712547 + 312 WP_098941657.1 monooxygenase -
GTH25_RS17015 3712597..3713145 - 549 WP_109419323.1 GNAT family N-acetyltransferase -
GTH25_RS17020 3713148..3714620 - 1473 WP_075671240.1 glycosyltransferase family 39 protein -
GTH25_RS17025 3714809..3715306 + 498 WP_075671238.1 Der GTPase-activating protein YihI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.78 Da        Isoelectric Point: 9.9411

>T146032 WP_075671248.1 NZ_CP047349:3710386-3710640 [Proteus terrae subsp. cibarius]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Download         Length: 255 bp

>T146032 NZ_CP062717:4506060-4506320 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.77 Da        Isoelectric Point: 4.4354

>AT146032 WP_072068851.1 NZ_CP047349:3710138-3710389 [Proteus terrae subsp. cibarius]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Download         Length: 252 bp

>AT146032 NZ_CP062717:4505781-4506041 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References