Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2298478..2298892 Replicon chromosome
Accession NZ_CP047321
Organism Staphylococcus aureus strain RJ1267

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GSF72_RS11765 Protein ID WP_048665700.1
Coordinates 2298641..2298892 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GSF72_RS14855 Protein ID WP_000028424.1
Coordinates 2298478..2298651 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF72_RS11725 2294558..2295832 - 1275 WP_048665702.1 PBSX family phage terminase large subunit -
GSF72_RS11730 2295819..2296259 - 441 WP_001003271.1 terminase small subunit -
GSF72_RS11735 2296445..2296864 - 420 WP_000058632.1 transcriptional regulator -
GSF72_RS11740 2296879..2297025 - 147 WP_000989998.1 hypothetical protein -
GSF72_RS11745 2297026..2297241 - 216 WP_048665701.1 hypothetical protein -
GSF72_RS11750 2297234..2297470 - 237 WP_000483477.1 hypothetical protein -
GSF72_RS11755 2297495..2297731 - 237 WP_000195831.1 DUF1381 domain-containing protein -
GSF72_RS11760 2297768..2298301 - 534 WP_031807824.1 dUTPase -
GSF72_RS14850 2298316..2298477 - 162 WP_000889682.1 hypothetical protein -
GSF72_RS14855 2298478..2298651 - 174 WP_000028424.1 hypothetical protein Antitoxin
GSF72_RS11765 2298641..2298892 - 252 WP_048665700.1 DUF1024 family protein Toxin
GSF72_RS11770 2298885..2299202 - 318 WP_031903325.1 hypothetical protein -
GSF72_RS14860 2299197..2299430 - 234 Protein_2284 hypothetical protein -
GSF72_RS11775 2299436..2299897 - 462 WP_048665699.1 hypothetical protein -
GSF72_RS11780 2299894..2300088 - 195 WP_048665698.1 hypothetical protein -
GSF72_RS11785 2300085..2300489 - 405 WP_000695764.1 hypothetical protein -
GSF72_RS11790 2300503..2300751 - 249 WP_000178883.1 phi PVL orf 51-like protein -
GSF72_RS11795 2300760..2300960 - 201 WP_000235323.1 hypothetical protein -
GSF72_RS11800 2300963..2301220 - 258 WP_000022739.1 DUF3310 domain-containing protein -
GSF72_RS11805 2301220..2301591 - 372 WP_000241093.1 hypothetical protein -
GSF72_RS11810 2301592..2301777 - 186 WP_029625657.1 DUF3113 family protein -
GSF72_RS11815 2301782..2302186 - 405 WP_000049789.1 DUF1064 domain-containing protein -
GSF72_RS11820 2302197..2302418 - 222 WP_001123695.1 DUF3269 family protein -
GSF72_RS11825 2302431..2302589 - 159 WP_123138749.1 hypothetical protein -
GSF72_RS11830 2302586..2303371 - 786 WP_159343914.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2274051..2313192 39141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9389.28 Da        Isoelectric Point: 3.8567

>T145971 WP_048665700.1 NZ_CP047321:c2298892-2298641 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T145971 NZ_CP062713:3759086-3759472 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT145971 WP_000028424.1 NZ_CP047321:c2298651-2298478 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT145971 NZ_CP062713:3759462-3759791 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References