Detailed information of TA system TA145963

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 993553..993735
• Replicon: chromosome
• Accession: NZ_CP047321
• Organism: Staphylococcus aureus strain RJ1267

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GSF72_RS05185
• Protein ID: WP_001801861.1
• Coordinates: 993640..993735 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	993553..993612 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSF72_RS05145	988553..988747	-	195	Protein_964	IS3 family transposase	-
GSF72_RS05150	989016..990011	-	996	WP_046464740.1	putative sulfate exporter family transporter	-
GSF72_RS05155	990126..990947	+	822	WP_000371597.1	LysR family transcriptional regulator	-
GSF72_RS05160	991085..991789	+	705	WP_048665789.1	helix-turn-helix domain-containing protein	-
GSF72_RS05165	991708..992637	+	930	WP_117206203.1	IS3 family transposase	-
GSF72_RS05170	992865..993068	+	204	Protein_969	DUF1433 domain-containing protein	-
GSF72_RS05175	993262..993438	+	177	Protein_970	transposase	-
GSF72_RS05180	993416..993517	-	102	WP_001791893.1	hypothetical protein	-
-	993553..993612	+	60	-	-	Antitoxin
GSF72_RS05185	993640..993735	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
GSF72_RS05190	993938..994081	+	144	WP_001549059.1	transposase	-
GSF72_RS05195	994685..995068	+	384	WP_000070812.1	hypothetical protein	-
GSF72_RS05200	995079..995255	+	177	WP_000375476.1	hypothetical protein	-
GSF72_RS05205	995257..995442	+	186	WP_000809857.1	hypothetical protein	-
GSF72_RS05210	995556..996197	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
GSF72_RS05215	996415..996966	-	552	WP_000414205.1	hypothetical protein	-
GSF72_RS05220	997064..997408	-	345	WP_000627551.1	DUF3969 family protein	-
GSF72_RS05225	997449..998075	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fusB	-	963141..1031175	68034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T145963 WP_001801861.1 NZ_CP047321:c993735-993640 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T145963 NZ_CP062713:2693593-2693748 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT145963 NZ_CP047321:993553-993612 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin