Detailed information of TA system TA145955

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 685578..685841
• Replicon: chromosome
• Accession: NZ_CP047321
• Organism: Staphylococcus aureus strain RJ1267

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: GSF72_RS03390
• Protein ID: WP_001802298.1
• Coordinates: 685578..685682 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	685677..685841 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSF72_RS03365	680962..681744	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
GSF72_RS03370	681812..682669	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
GSF72_RS03375	683374..683466	-	93	WP_001790138.1	hypothetical protein	-
GSF72_RS03380	683755..684891	+	1137	WP_000115562.1	SAP domain-containing protein	-
GSF72_RS03385	684934..685417	+	484	Protein_659	recombinase family protein	-
GSF72_RS03390	685578..685682	+	105	WP_001802298.1	hypothetical protein	Toxin
-	685677..685841	-	165	-	-	Antitoxin
GSF72_RS03395	686182..687273	-	1092	WP_000495671.1	lytic regulatory protein	-
GSF72_RS03400	687539..688519	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
GSF72_RS03405	688521..688841	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
GSF72_RS03410	688993..689658	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T145955 WP_001802298.1 NZ_CP047321:685578-685682 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T145955 NZ_CP062713:409381-409908 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT145955 NZ_CP047321:c685841-685677 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin