Detailed information of TA system TA145952

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 392536..392720
• Replicon: chromosome
• Accession: NZ_CP047321
• Organism: Staphylococcus aureus strain RJ1267

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: GSF72_RS01845
• Protein ID: WP_000482650.1
• Coordinates: 392536..392643 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	392660..392720 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSF72_RS01820	387899..388372	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
GSF72_RS01825	388495..389706	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GSF72_RS01830	389888..390547	-	660	WP_000831298.1	membrane protein	-
GSF72_RS01835	390607..391749	-	1143	WP_159343877.1	glycerate kinase	-
GSF72_RS01840	392017..392403	+	387	WP_000779358.1	flippase GtxA	-
GSF72_RS01845	392536..392643	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	392660..392720	-	61	-	-	Antitoxin
GSF72_RS01850	393271..395034	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
GSF72_RS01855	395059..396792	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
GSF72_RS01860	397023..397190	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T145952 WP_000482650.1 NZ_CP047321:392536-392643 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T145952 NZ_CP062712:71587-71745 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT145952 NZ_CP047321:c392720-392660 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin