145951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 360698..361221 Replicon chromosome
Accession NZ_CP047321
Organism Staphylococcus aureus strain RJ1267

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag GSF72_RS01705 Protein ID WP_000074048.1
Coordinates 360955..361221 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag GSF72_RS01700 Protein ID WP_000587616.1
Coordinates 360698..360955 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF72_RS01680 355779..356972 + 1194 WP_000675401.1 MFS transporter -
GSF72_RS01685 357196..357945 - 750 WP_000072443.1 hypothetical protein -
GSF72_RS01690 358140..359717 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
GSF72_RS01695 359885..360340 - 456 WP_000732082.1 DUF1307 domain-containing protein -
GSF72_RS01700 360698..360955 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GSF72_RS01705 360955..361221 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
GSF72_RS01710 361576..362652 + 1077 WP_001076671.1 M42 family metallopeptidase -
GSF72_RS01715 362899..363561 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
GSF72_RS01720 363554..364330 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
GSF72_RS01725 364726..365913 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T145951 WP_000074048.1 NZ_CP047321:360955-361221 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T145951 NZ_CP062712:51520-51825 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT145951 WP_000587616.1 NZ_CP047321:360698-360955 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT145951 NZ_CP062712:51300-51518 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References