Detailed information of TA system TA145800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1664615..1665195
• Replicon: chromosome
• Accession: NZ_CP047289
• Organism: Falsirhodobacter sp. PG104

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GR316_RS08330
• Protein ID: WP_211783489.1
• Coordinates: 1664615..1664896 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: GR316_RS08335
• Protein ID: WP_211783490.1
• Coordinates: 1664908..1665195 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GR316_RS08300 (GR316_08265)	1660652..1661392	-	741	Protein_1619	IS5 family transposase	-
GR316_RS08310 (GR316_08275)	1662702..1663001	+	300	WP_211783485.1	plasmid mobilization relaxosome protein MobC	-
GR316_RS08315 (GR316_08280)	1663367..1663591	+	225	WP_211783486.1	hypothetical protein	-
GR316_RS08320 (GR316_08285)	1663695..1664171	+	477	WP_211783487.1	hypothetical protein	-
GR316_RS08325 (GR316_08290)	1664173..1664583	+	411	WP_211783488.1	hypothetical protein	-
GR316_RS08330 (GR316_08295)	1664615..1664896	+	282	WP_211783489.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GR316_RS08335 (GR316_08300)	1664908..1665195	+	288	WP_211783490.1	HigA family addiction module antitoxin	Antitoxin
GR316_RS08340 (GR316_08305)	1665332..1668469	-	3138	WP_211783491.1	type I restriction endonuclease subunit R	-
GR316_RS08345 (GR316_08310)	1668466..1669755	-	1290	WP_211783492.1	FRG domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1657166..1676571	19405

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10255.82 Da
• Isoelectric Point: 10.0531

>T145800 WP_211783489.1 NZ_CP047289:1664615-1664896 [Falsirhodobacter sp. PG104]
MIQSAKGKLATNALQGKYGKGFPADLVKRTRAMLTALHAAVAVEDLRFPPGNNLEELKGDRAGQHSVRINGQWRICFVWT
PKGPAEVEIVDYH

Nucleotide

• Length: 282 bp

>T145800 NZ_CP062699:3628034-3628471 [Pseudomonas taiwanensis]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGTCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCGACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCTCAGCCTGAGTTGACCCGTACGCTGGGCAATCGTTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACGCCGGACAGCCGCCTGTTCTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10689.45 Da
• Isoelectric Point: 5.6400

>AT145800 WP_211783490.1 NZ_CP047289:1664908-1665195 [Falsirhodobacter sp. PG104]
MSLLQDPMHPGEVLKELYLDPLEIGAIALARRLGVPRTRIERLVKGATSMTPDTALRLARVFNTTPDYWMNMQTNFDMHA
AIQQIDVSNIEPLVA

Nucleotide

• Length: 288 bp

>AT145800 NZ_CP062699:3627588-3628037 [Pseudomonas taiwanensis]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGCGATTTCGAAATCCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCTGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAGCGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA