Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 34541..35189 | Replicon | chromosome |
Accession | NZ_CP047279 | ||
Organism | Citrobacter freundii strain N18-04128 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0D7M266 |
Locus tag | F3113_RS00170 | Protein ID | WP_016151211.1 |
Coordinates | 34541..34903 (+) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0D7LEH2 |
Locus tag | F3113_RS00175 | Protein ID | WP_003840660.1 |
Coordinates | 34890..35189 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F3113_RS00155 | 31000..32328 | + | 1329 | WP_003023927.1 | MFS transporter | - |
F3113_RS00160 | 32471..33862 | + | 1392 | WP_003023929.1 | hexose-6-phosphate:phosphate antiporter | - |
F3113_RS00165 | 33988..34440 | + | 453 | WP_003023933.1 | DUF1198 family protein | - |
F3113_RS00170 | 34541..34903 | + | 363 | WP_016151211.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
F3113_RS00175 | 34890..35189 | + | 300 | WP_003840660.1 | helix-turn-helix transcriptional regulator | Antitoxin |
F3113_RS00180 | 35308..36501 | + | 1194 | WP_003840662.1 | purine ribonucleoside efflux pump NepI | - |
F3113_RS00185 | 36550..37932 | - | 1383 | WP_016151210.1 | glycoside hydrolase family 1 protein | - |
F3113_RS00190 | 38027..38320 | - | 294 | WP_003840665.1 | hypothetical protein | - |
F3113_RS00195 | 38451..38867 | + | 417 | WP_003023951.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13788.66 Da Isoelectric Point: 5.1976
>T145751 WP_016151211.1 NZ_CP047279:34541-34903 [Citrobacter freundii]
MWEVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKELRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLISKENYGYP
MWEVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKELRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLISKENYGYP
Download Length: 363 bp
>T145751 NZ_CP062467:54657-54845 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11016.85 Da Isoelectric Point: 8.5047
>AT145751 WP_003840660.1 NZ_CP047279:34890-35189 [Citrobacter freundii]
MATLKELMAKQSPESQERITEKVEILRQAVALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFYL
MATLKELMAKQSPESQERITEKVEILRQAVALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFYL
Download Length: 300 bp
>AT145751 NZ_CP062467:54368-54628 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7M266 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7LEH2 |