Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2407241..2407879 Replicon chromosome
Accession NZ_CP047277
Organism Escherichia coli strain N18-04097

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag F3052_RS11580 Protein ID WP_000813794.1
Coordinates 2407703..2407879 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F3052_RS11575 Protein ID WP_001270286.1
Coordinates 2407241..2407657 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3052_RS11555 2402393..2403334 - 942 WP_001251304.1 ABC transporter permease -
F3052_RS11560 2403335..2404348 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
F3052_RS11565 2404366..2405511 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
F3052_RS11570 2405756..2407162 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
F3052_RS11575 2407241..2407657 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
F3052_RS11580 2407703..2407879 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
F3052_RS11585 2408101..2408331 + 231 WP_000494244.1 YncJ family protein -
F3052_RS11590 2408423..2410384 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
F3052_RS11595 2410457..2410993 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
F3052_RS11600 2411046..2412260 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2412300..2413448 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T145742 WP_000813794.1 NZ_CP047277:c2407879-2407703 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T145742 NZ_CP062465:513126-513233 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT145742 WP_001270286.1 NZ_CP047277:c2407657-2407241 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT145742 NZ_CP062465:c513310-513250 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References