145708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 384819..385485 Replicon chromosome
Accession NZ_CP047275
Organism Citrobacter freundii strain N18-04085

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag F3084_RS01790 Protein ID WP_003847996.1
Coordinates 385168..385485 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag F3084_RS01785 Protein ID WP_003837894.1
Coordinates 384819..385115 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3084_RS01770 381995..382468 - 474 WP_003023524.1 transcription elongation factor GreB -
F3084_RS01775 382694..383413 + 720 WP_001157751.1 two-component system response regulator OmpR -
F3084_RS01780 383410..384762 + 1353 WP_183273575.1 two-component system sensor histidine kinase EnvZ -
F3084_RS01785 384819..385115 - 297 WP_003837894.1 helix-turn-helix domain-containing protein Antitoxin
F3084_RS01790 385168..385485 - 318 WP_003847996.1 hypothetical protein Toxin
F3084_RS01795 385608..387230 - 1623 WP_044701411.1 phosphoenolpyruvate carboxykinase (ATP) -
F3084_RS01800 387609..389327 + 1719 WP_183273576.1 DUF4153 domain-containing protein -
F3084_RS01805 389437..390315 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T145708 WP_003847996.1 NZ_CP047275:c385485-385168 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

>T145708 NZ_CP062419:2307047-2307154 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT145708 WP_003837894.1 NZ_CP047275:c385115-384819 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp

>AT145708 NZ_CP062419:c2307231-2307171 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References