Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3883589..3884186 Replicon chromosome
Accession NZ_CP047271
Organism Klebsiella pneumoniae strain N16-03892

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag F3090_RS19240 Protein ID WP_004893639.1
Coordinates 3883869..3884186 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag F3090_RS19235 Protein ID WP_004142561.1
Coordinates 3883589..3883876 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3090_RS19205 3879669..3879917 + 249 WP_002893037.1 DUF1158 domain-containing protein -
F3090_RS19210 3879935..3880276 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
F3090_RS19215 3880307..3881422 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
F3090_RS19220 3881602..3882183 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
F3090_RS19225 3882183..3882551 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
F3090_RS19230 3882671..3883324 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
F3090_RS19235 3883589..3883876 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
F3090_RS19240 3883869..3884186 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3090_RS19245 3884371..3885414 - 1044 WP_009308098.1 DUF2157 domain-containing protein -
F3090_RS19250 3886080..3886946 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
F3090_RS19255 3887055..3888482 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T145675 WP_004893639.1 NZ_CP047271:c3884186-3883869 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T145675 NZ_CP062416:c182871-182776 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT145675 WP_004142561.1 NZ_CP047271:c3883876-3883589 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT145675 NZ_CP062416:182691-182748 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References