145628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1934400..1934919 Replicon chromosome
Accession NZ_CP047248
Organism Streptococcus suis strain LSM178

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag GRI05_RS09545 Protein ID WP_012775363.1
Coordinates 1934400..1934657 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag GRI05_RS09550 Protein ID WP_002939010.1
Coordinates 1934659..1934919 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI05_RS09530 1930869..1932599 - 1731 WP_012775361.1 membrane protein -
GRI05_RS09535 1932964..1933872 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GRI05_RS09540 1933856..1934386 - 531 WP_009910909.1 DUF1697 domain-containing protein -
GRI05_RS09545 1934400..1934657 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
GRI05_RS09550 1934659..1934919 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GRI05_RS09555 1934995..1935450 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
GRI05_RS09560 1935457..1935786 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
GRI05_RS09565 1935776..1936063 - 288 WP_012028535.1 hypothetical protein -
GRI05_RS09570 1936161..1936529 - 369 WP_012775453.1 hypothetical protein -
GRI05_RS09575 1936522..1937091 - 570 WP_012775366.1 ribonuclease M5 -
GRI05_RS09580 1937075..1937857 - 783 WP_012028536.1 TatD family hydrolase -
GRI05_RS09585 1937964..1938101 - 138 WP_002939016.1 50S ribosomal protein L34 -
GRI05_RS09590 1938269..1939264 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T145628 WP_012775363.1 NZ_CP047248:c1934657-1934400 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T145628 NZ_CP062411:2760872-2761123 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT145628 WP_002939010.1 NZ_CP047248:c1934919-1934659 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT145628 NZ_CP062411:2761113-2761286 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGATGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References