Detailed information of TA system TA145621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5343997..5344604
• Replicon: chromosome
• Accession: NZ_CP047242
• Organism: Trichormus variabilis 0441

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GSQ19_RS22045
• Protein ID: WP_011319973.1
• Coordinates: 5343997..5344281 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GSQ19_RS22050
• Protein ID: WP_011319974.1
• Coordinates: 5344296..5344604 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSQ19_RS22025	5339296..5342139	+	2844	WP_011319969.1	DUF3987 domain-containing protein	-
GSQ19_RS22030	5342218..5342373	+	156	WP_011319970.1	hypothetical protein	-
GSQ19_RS22035	5342541..5343128	+	588	WP_011319971.1	hypothetical protein	-
GSQ19_RS22040	5343348..5343779	-	432	WP_011319972.1	hypothetical protein	-
GSQ19_RS22045	5343997..5344281	+	285	WP_011319973.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GSQ19_RS22050	5344296..5344604	+	309	WP_011319974.1	HigA family addiction module antidote protein	Antitoxin
GSQ19_RS22055	5344633..5347032	-	2400	WP_011319975.1	NACHT domain-containing NTPase	-
GSQ19_RS22060	5347189..5347413	-	225	WP_153228420.1	hypothetical protein	-
GSQ19_RS22065	5347520..5348449	+	930	WP_011319977.1	caspase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-94)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10826.24 Da
• Isoelectric Point: 5.0914

>T145621 WP_011319973.1 NZ_CP047242:5343997-5344281 [Trichormus variabilis 0441]
VIVNFKSEETKLIFEGFTSSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLVGDRSGQYSIRINDQWRICFVWT
DENNASEVEIVDYH

Nucleotide

• Length: 285 bp

>T145621 NZ_CP062411:1200149-1200337 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11699.17 Da
• Isoelectric Point: 5.6642

>AT145621 WP_011319974.1 NZ_CP047242:5344296-5344604 [Trichormus variabilis 0441]
MNNNRLPNIHPGEILKLDFLEPLNITAYRLSKDIGVTQTRISEILSGKRSITADTALRLSHYFGNTAQFWLNLQTQYDLR
QALEENSEVYNQISKFLSDDVA

Nucleotide

• Length: 309 bp

>AT145621 NZ_CP062411:1199860-1200120 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA