Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3006899..3007592 Replicon chromosome
Accession NZ_CP047231
Organism Escherichia coli strain BL21-AI

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GSU80_RS14515 Protein ID WP_000415584.1
Coordinates 3007296..3007592 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GSU80_RS14510 Protein ID WP_000650107.1
Coordinates 3006899..3007294 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSU80_RS14500 3002763..3005021 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
GSU80_RS14505 3005159..3006766 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GSU80_RS14510 3006899..3007294 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GSU80_RS14515 3007296..3007592 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GSU80_RS14520 3007797..3008279 - 483 WP_000183505.1 transcriptional regulator -
GSU80_RS14525 3008332..3008724 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GSU80_RS14530 3008876..3009535 + 660 WP_001221493.1 two-component system response regulator QseB -
GSU80_RS14535 3009532..3010881 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
GSU80_RS14540 3010927..3011259 - 333 WP_000917684.1 DUF2645 family protein -
GSU80_RS14545 3011578..3012159 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
GSU80_RS14550 3012190..3012504 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T145606 WP_000415584.1 NZ_CP047231:c3007592-3007296 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T145606 NZ_CP062409:2661216-2661578 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT145606 WP_000650107.1 NZ_CP047231:c3007294-3006899 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT145606 NZ_CP062409:2661049-2661219 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References