Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1434960..1435598 Replicon chromosome
Accession NZ_CP047231
Organism Escherichia coli strain BL21-AI

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag GSU80_RS07040 Protein ID WP_000813794.1
Coordinates 1434960..1435136 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GSU80_RS07045 Protein ID WP_001270286.1
Coordinates 1435182..1435598 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSU80_RS07020 1430579..1431793 - 1215 WP_001326689.1 BenE family transporter YdcO -
GSU80_RS07025 1431846..1432382 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
GSU80_RS07030 1432455..1434416 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
GSU80_RS07035 1434508..1434738 - 231 WP_000494244.1 YncJ family protein -
GSU80_RS07040 1434960..1435136 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
GSU80_RS07045 1435182..1435598 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
GSU80_RS07050 1435677..1437083 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
GSU80_RS07055 1437328..1438473 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
GSU80_RS07060 1438491..1439504 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
GSU80_RS07065 1439505..1440446 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1429391..1430539 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T145594 WP_000813794.1 NZ_CP047231:1434960-1435136 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T145594 NZ_CP062408:2673164-2673268 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT145594 WP_001270286.1 NZ_CP047231:1435182-1435598 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT145594 NZ_CP062408:c2673426-2673263 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References