Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4060..4652 | Replicon | plasmid p3 |
Accession | NZ_CP047229 | ||
Organism | Moraxella osloensis strain YV1 |
Toxin (Protein)
Gene name | graT | Uniprot ID | A0A120KR99 |
Locus tag | GSF12_RS12740 | Protein ID | WP_062335123.1 |
Coordinates | 4060..4341 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A120KRC1 |
Locus tag | GSF12_RS12745 | Protein ID | WP_062335121.1 |
Coordinates | 4356..4652 (+) | Length | 99 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GSF12_RS12710 | 639..866 | - | 228 | WP_062335103.1 | helix-turn-helix transcriptional regulator | - |
GSF12_RS12715 | 1040..1324 | + | 285 | WP_159375883.1 | hypothetical protein | - |
GSF12_RS12720 | 1384..1749 | + | 366 | WP_159375884.1 | hypothetical protein | - |
GSF12_RS12725 | 1868..2314 | - | 447 | WP_159375885.1 | hypothetical protein | - |
GSF12_RS12730 | 2662..3132 | + | 471 | WP_159375886.1 | plasmid mobilization relaxosome protein MobC | - |
GSF12_RS12735 | 3215..3724 | + | 510 | WP_159375887.1 | relaxase/mobilization nuclease domain-containing protein | - |
GSF12_RS12740 | 4060..4341 | + | 282 | WP_062335123.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GSF12_RS12745 | 4356..4652 | + | 297 | WP_062335121.1 | HigA family addiction module antidote protein | Antitoxin |
GSF12_RS12750 | 4759..5921 | + | 1163 | WP_159375888.1 | IS3 family transposase | - |
GSF12_RS12755 | 6181..6510 | - | 330 | WP_159375889.1 | hypothetical protein | - |
GSF12_RS12760 | 6510..7271 | - | 762 | WP_159375890.1 | ParA family protein | - |
GSF12_RS12765 | 7433..7843 | - | 411 | WP_159374790.1 | IS200/IS605 family transposase | - |
GSF12_RS12770 | 7892..8995 | + | 1104 | WP_159375891.1 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..26254 | 26254 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10798.23 Da Isoelectric Point: 6.8610
>T145583 WP_062335123.1 NZ_CP047229:4060-4341 [Moraxella osloensis]
MIVNFACDKTKTLFTTGNTRHFSSIKKVAERKLLQLDNAITLEDLRSPPGNHLEALFGDREGQHSIRINDQWRICFVWTQ
EGPTEVEIVDYHR
MIVNFACDKTKTLFTTGNTRHFSSIKKVAERKLLQLDNAITLEDLRSPPGNHLEALFGDREGQHSIRINDQWRICFVWTQ
EGPTEVEIVDYHR
Download Length: 282 bp
>T145583 NZ_CP062407:2280537-2280857 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A
Antitoxin
Download Length: 99 a.a. Molecular weight: 11046.78 Da Isoelectric Point: 7.2020
>AT145583 WP_062335121.1 NZ_CP047229:4356-4652 [Moraxella osloensis]
MKNGMRPIHPGEILREDYLAPLEMSANALAKAIGVTPARINEIVREERGITADTALRLAKYFGGNAKFWLNLQTTYELRL
AETQDTHFLDKIMPLAFS
MKNGMRPIHPGEILREDYLAPLEMSANALAKAIGVTPARINEIVREERGITADTALRLAKYFGGNAKFWLNLQTTYELRL
AETQDTHFLDKIMPLAFS
Download Length: 297 bp
>AT145583 NZ_CP062407:2280325-2280534 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A120KR99 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A120KRC1 |