145540

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 775727..776502 Replicon chromosome
Accession NZ_CP047192
Organism Klebsiella pneumoniae strain Kp36

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag GS419_RS03920 Protein ID WP_004150910.1
Coordinates 776017..776502 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag GS419_RS03915 Protein ID WP_004150912.1
Coordinates 775727..776020 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS419_RS03895 770935..771537 - 603 WP_062954968.1 short chain dehydrogenase -
GS419_RS03900 771635..772546 + 912 WP_004188550.1 LysR family transcriptional regulator -
GS419_RS03905 772547..773695 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
GS419_RS03910 773706..775082 - 1377 WP_004217775.1 cystathionine beta-synthase -
GS419_RS03915 775727..776020 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
GS419_RS03920 776017..776502 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
GS419_RS03925 777206..777799 + 594 WP_004188553.1 hypothetical protein -
GS419_RS03930 777896..778112 + 217 Protein_780 transposase -
GS419_RS03945 778718..779590 + 873 WP_004188557.1 ParA family protein -
GS419_RS03950 779590..779973 + 384 WP_004150906.1 hypothetical protein -
GS419_RS03955 779966..781333 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 777896..778048 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T145540 WP_004150910.1 NZ_CP047192:776017-776502 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T145540 NZ_CP062403:2273157-2273423 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT145540 WP_004150912.1 NZ_CP047192:775727-776020 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT145540 NZ_CP062403:2272900-2273157 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References