145452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2584934..2585627 Replicon chromosome
Accession NZ_CP047127
Organism Escherichia coli K-12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GRF62_RS12375 Protein ID WP_000415584.1
Coordinates 2584934..2585230 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GRF62_RS12380 Protein ID WP_000650107.1
Coordinates 2585232..2585627 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRF62_RS12340 2580022..2580336 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
GRF62_RS12345 2580367..2580948 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GRF62_RS12350 2581267..2581599 + 333 WP_000917684.1 DUF2645 family protein -
GRF62_RS12355 2581645..2582994 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
GRF62_RS12360 2582991..2583650 - 660 WP_001221495.1 two-component system response regulator QseB -
GRF62_RS12365 2583802..2584194 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GRF62_RS12370 2584247..2584729 + 483 WP_000183505.1 transcriptional regulator -
GRF62_RS12375 2584934..2585230 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GRF62_RS12380 2585232..2585627 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GRF62_RS12385 2585760..2587367 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GRF62_RS12390 2587505..2589763 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T145452 WP_000415584.1 NZ_CP047127:2584934-2585230 [Escherichia coli K-12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T145452 NZ_CP062386:2336536-2336802 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT145452 WP_000650107.1 NZ_CP047127:2585232-2585627 [Escherichia coli K-12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT145452 NZ_CP062386:2336285-2336536 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References