Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 127649..127907 Replicon chromosome
Accession NZ_CP047057
Organism Escherichia coli NC101

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag GQ584_RS00610 Protein ID WP_000809168.1
Coordinates 127649..127801 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 127850..127907 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ584_RS00590 122894..123607 - 714 WP_001102393.1 acidic protein MsyB -
GQ584_RS00595 123633..124037 - 405 WP_000843692.1 DUF2541 family protein -
GQ584_RS00600 124409..126325 + 1917 WP_000516135.1 molecular chaperone DnaK -
GQ584_RS00605 126414..127544 + 1131 WP_001118464.1 molecular chaperone DnaJ -
GQ584_RS00610 127649..127801 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 127850..127907 + 58 - - Antitoxin
GQ584_RS00615 128416..129177 + 762 WP_001274832.1 outer membrane protein OmpK -
GQ584_RS00620 129197..130690 + 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
GQ584_RS00625 130819..132078 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T145365 WP_000809168.1 NZ_CP047057:c127801-127649 [Escherichia coli NC101]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T145365 NZ_CP062366:1272290-1272478 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 58 bp

>AT145365 NZ_CP047057:127850-127907 [Escherichia coli NC101]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References