Detailed information of TA system TA145362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 966298..966863
• Replicon: chromosome
• Accession: NZ_CP047056
• Organism: Succinivibrio dextrinosolvens strain Z6

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: SDZ_RS04130
• Protein ID: WP_074840657.1
• Coordinates: 966585..966863 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A662Z9A6
• Locus tag: SDZ_RS04125
• Protein ID: WP_074840659.1
• Coordinates: 966298..966585 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDZ_RS04110	962160..963788	+	1629	WP_164954247.1	AAA family ATPase	-
SDZ_RS04115	964115..964318	-	204	WP_074840663.1	helix-turn-helix domain-containing protein	-
SDZ_RS04120	964446..966029	+	1584	WP_164954248.1	AAA family ATPase	-
SDZ_RS04125	966298..966585	-	288	WP_074840659.1	HigA family addiction module antidote protein	Antitoxin
SDZ_RS04130	966585..966863	-	279	WP_074840657.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SDZ_RS04135	967457..967867	+	411	WP_074840653.1	TIGR04076 family protein	-
SDZ_RS04140	968050..968697	-	648	WP_083396932.1	flagellin	-
SDZ_RS04145	968658..968969	-	312	WP_083396931.1	hypothetical protein	-
SDZ_RS04150	969353..970126	-	774	WP_074840651.1	MipA/OmpV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-63)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10872.50 Da
• Isoelectric Point: 9.9971

>T145362 WP_074840657.1 NZ_CP047056:c966863-966585 [Succinivibrio dextrinosolvens]
MIKSFKHKGLKEFFLNGSTKGIQQKDQKRLRYLLALLNHASEITDLNISGLFLHKLKGDRQDIWSVRVSANWRLTFQFVN
GDVYILDYEDYH

Nucleotide

• Length: 279 bp

>T145362 NZ_CP062366:18831-19007 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10674.37 Da
• Isoelectric Point: 5.6492

>AT145362 WP_074840659.1 NZ_CP047056:c966585-966298 [Succinivibrio dextrinosolvens]
MKMFNPPHPGFMLSMLLEDNNIKAKDLAKQIHVSPSTISRLLKEKISLSPELAVKLAAAFGNPTTNMWLGFQADYDAWEV
EQNIDVSNIERFVLG

Nucleotide

• Length: 288 bp

>AT145362 NZ_CP062366:c19169-18995 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin

• AlphaFold DB: A0A662Z9A6