145351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2507023..2507546 Replicon chromosome
Accession NZ_CP047021
Organism Staphylococcus aureus strain M2024

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GQX63_RS12500 Protein ID WP_045177693.1
Coordinates 2507023..2507289 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GQX63_RS12505 Protein ID WP_086095185.1
Coordinates 2507289..2507546 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX63_RS12480 2502329..2503516 - 1188 WP_045177690.1 MFS transporter -
GQX63_RS12485 2503912..2504688 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
GQX63_RS12490 2504681..2505343 - 663 WP_045177691.1 ATP-binding cassette domain-containing protein -
GQX63_RS12495 2505591..2506667 - 1077 WP_001076673.1 M42 family metallopeptidase -
GQX63_RS12500 2507023..2507289 - 267 WP_045177693.1 Txe/YoeB family addiction module toxin Toxin
GQX63_RS12505 2507289..2507546 - 258 WP_086095185.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX63_RS12510 2507906..2508361 + 456 WP_000732090.1 YehR family lipoprotein -
GQX63_RS12515 2508529..2510106 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
GQX63_RS12520 2510301..2511050 + 750 WP_000072443.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10684.35 Da        Isoelectric Point: 10.1384

>T145351 WP_045177693.1 NZ_CP047021:c2507289-2507023 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T145351 NZ_CP062362:2297779-2297886 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9704.75 Da        Isoelectric Point: 4.2813

>AT145351 WP_086095185.1 NZ_CP047021:c2507546-2507289 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKGNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT145351 NZ_CP062362:c2297963-2297903 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References