Detailed information of TA system TA145349

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2475823..2476007
• Replicon: chromosome
• Accession: NZ_CP047021
• Organism: Staphylococcus aureus strain M2024

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: GQX63_RS12360
• Protein ID: WP_000482647.1
• Coordinates: 2475900..2476007 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2475823..2475883 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX63_RS12345	2471274..2471441	-	168	WP_001790576.1	hypothetical protein	-
GQX63_RS12350	2471672..2473405	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
GQX63_RS12355	2473430..2475193	-	1764	WP_103146941.1	ABC transporter ATP-binding protein/permease	-
-	2475823..2475883	+	61	-	-	Antitoxin
GQX63_RS12360	2475900..2476007	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
GQX63_RS12365	2476141..2476527	-	387	WP_000779360.1	flippase GtxA	-
GQX63_RS12370	2476795..2477937	+	1143	WP_001176863.1	glycerate kinase	-
GQX63_RS12375	2477997..2478656	+	660	WP_000831298.1	membrane protein	-
GQX63_RS12380	2478838..2480049	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GQX63_RS12385	2480172..2480645	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T145349 WP_000482647.1 NZ_CP047021:c2476007-2475900 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T145349 NZ_CP062362:c1599718-1599401 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT145349 NZ_CP047021:2475823-2475883 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin