Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2450482..2450999 Replicon chromosome
Accession NZ_CP047021
Organism Staphylococcus aureus strain M2024

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag GQX63_RS12225 Protein ID WP_000113262.1
Coordinates 2450482..2450748 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag GQX63_RS12230 Protein ID WP_000584499.1
Coordinates 2450748..2450999 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX63_RS12200 2445909..2446445 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
GQX63_RS12205 2446678..2447502 - 825 WP_045177662.1 formate/nitrite transporter family protein -
GQX63_RS12210 2447719..2447901 - 183 WP_000230294.1 hypothetical protein -
GQX63_RS12215 2447985..2448452 - 468 WP_000153346.1 SRPBCC domain-containing protein -
GQX63_RS12220 2448638..2450188 - 1551 WP_045177665.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
GQX63_RS12225 2450482..2450748 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
GQX63_RS12230 2450748..2450999 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX63_RS12235 2451164..2451265 - 102 WP_001791744.1 hypothetical protein -
GQX63_RS12240 2451272..2451871 - 600 WP_000162812.1 DsbA family protein -
GQX63_RS12245 2451890..2452252 - 363 WP_000819843.1 DUF4467 domain-containing protein -
GQX63_RS12250 2452507..2453757 + 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
GQX63_RS12255 2453854..2454585 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
GQX63_RS12260 2454582..2455301 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T145348 WP_000113262.1 NZ_CP047021:c2450748-2450482 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T145348 NZ_CP062362:1161611-1161799 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT145348 WP_000584499.1 NZ_CP047021:c2450999-2450748 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT145348 NZ_CP062362:1161322-1161582 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References