Detailed information of TA system TA145340

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2022642..2022949
• Replicon: chromosome
• Accession: NZ_CP047021
• Organism: Staphylococcus aureus strain M2024

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: GQX63_RS09930
• Protein ID: WP_011447039.1
• Coordinates: 2022773..2022949 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2022642..2022781 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX63_RS09890	2018207..2018386	+	180	WP_000669791.1	hypothetical protein	-
GQX63_RS09895	2018697..2018957	+	261	WP_001791826.1	hypothetical protein	-
GQX63_RS09900	2019010..2019360	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
GQX63_RS09905	2019872..2020207	-	336	Protein_1907	SH3 domain-containing protein	-
GQX63_RS09910	2020858..2021349	-	492	WP_000920038.1	staphylokinase	-
GQX63_RS09915	2021540..2022295	-	756	WP_000861038.1	CHAP domain-containing protein	-
GQX63_RS09920	2022307..2022561	-	255	WP_000611512.1	phage holin	-
GQX63_RS09925	2022613..2022720	+	108	WP_031762631.1	hypothetical protein	-
-	2022642..2022781	+	140	NuclAT_0	-	Antitoxin
-	2022642..2022781	+	140	NuclAT_0	-	Antitoxin
-	2022642..2022781	+	140	NuclAT_0	-	Antitoxin
-	2022642..2022781	+	140	NuclAT_0	-	Antitoxin
GQX63_RS09930	2022773..2022949	-	177	WP_011447039.1	putative holin-like toxin	Toxin
GQX63_RS09935	2023058..2023831	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
GQX63_RS09940	2024204..2024578	-	375	WP_000340977.1	hypothetical protein	-
GQX63_RS09945	2024634..2024921	-	288	WP_001262621.1	hypothetical protein	-
GQX63_RS09950	2024967..2025119	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2019010..2075692	56682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T145340 WP_011447039.1 NZ_CP047021:c2022949-2022773 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T145340 NZ_CP062360:c2078233-2077871 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT145340 NZ_CP047021:2022642-2022781 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin