Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1882500..1882914 Replicon chromosome
Accession NZ_CP047021
Organism Staphylococcus aureus strain M2024

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GQX63_RS08990 Protein ID WP_001826875.1
Coordinates 1882663..1882914 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQX63_RS08985 Protein ID WP_000028424.1
Coordinates 1882500..1882673 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX63_RS08930 1877842..1879050 - 1209 WP_031927907.1 PBSX family phage terminase large subunit -
GQX63_RS08935 1879043..1879537 - 495 WP_072328463.1 terminase small subunit -
GQX63_RS08940 1879627..1879938 - 312 WP_029550564.1 hypothetical protein -
GQX63_RS08945 1880288..1880689 - 402 WP_000286968.1 hypothetical protein -
GQX63_RS08950 1880690..1880863 - 174 WP_176325154.1 transcriptional activator RinB -
GQX63_RS08955 1880866..1881066 - 201 WP_001125015.1 hypothetical protein -
GQX63_RS08960 1881041..1881229 - 189 WP_000195817.1 DUF1381 domain-containing protein -
GQX63_RS08965 1881226..1881471 - 246 WP_001282074.1 hypothetical protein -
GQX63_RS08970 1881508..1882041 - 534 WP_001061841.1 dUTPase -
GQX63_RS08975 1882056..1882217 - 162 WP_000889679.1 hypothetical protein -
GQX63_RS08980 1882218..1882499 - 282 WP_000454993.1 hypothetical protein -
GQX63_RS08985 1882500..1882673 - 174 WP_000028424.1 hypothetical protein Antitoxin
GQX63_RS08990 1882663..1882914 - 252 WP_001826875.1 DUF1024 family protein Toxin
GQX63_RS08995 1882929..1883171 - 243 WP_000131389.1 hypothetical protein -
GQX63_RS09000 1883175..1883543 - 369 WP_016028254.1 hypothetical protein -
GQX63_RS14005 1883544..1883729 - 186 WP_016028253.1 DUF3113 family protein -
GQX63_RS09005 1883734..1884138 - 405 WP_000049798.1 DUF1064 domain-containing protein -
GQX63_RS09010 1884149..1884370 - 222 WP_001123681.1 DUF3269 family protein -
GQX63_RS09015 1884384..1884542 - 159 WP_000256589.1 hypothetical protein -
GQX63_RS09020 1884536..1885309 - 774 WP_000803028.1 ATP-binding protein -
GQX63_RS09025 1885319..1886089 - 771 WP_000190226.1 conserved phage C-terminal domain-containing protein -
GQX63_RS09030 1886135..1886794 + 660 WP_016028252.1 hypothetical protein -
GQX63_RS09035 1886904..1887575 - 672 WP_016028251.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1814812..1897273 82461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9489.40 Da        Isoelectric Point: 3.9476

>T145338 WP_001826875.1 NZ_CP047021:c1882914-1882663 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T145338 NZ_CP062360:c1870050-1869898 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGGACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAGGACAGTCAGTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT145338 WP_000028424.1 NZ_CP047021:c1882673-1882500 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT145338 NZ_CP062360:c1870674-1870075 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTTATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References