Detailed information of TA system TA145336

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1821702..1821884
• Replicon: chromosome
• Accession: NZ_CP047021
• Organism: Staphylococcus aureus strain M2024

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GQX63_RS08650
• Protein ID: WP_001801861.1
• Coordinates: 1821702..1821797 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1821825..1821884 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX63_RS08610	1817372..1817998	+	627	WP_045177256.1	hypothetical protein	-
GQX63_RS08615	1818039..1818380	+	342	WP_045177258.1	DUF3969 family protein	-
GQX63_RS08620	1818481..1819053	+	573	WP_045177260.1	hypothetical protein	-
GQX63_RS08625	1819251..1819808	-	558	WP_045177261.1	ImmA/IrrE family metallo-endopeptidase	-
GQX63_RS08630	1819994..1820158	-	165	WP_001793442.1	hypothetical protein	-
GQX63_RS08635	1820182..1820358	-	177	WP_000375477.1	hypothetical protein	-
GQX63_RS08640	1820369..1820752	-	384	WP_000070811.1	hypothetical protein	-
GQX63_RS08645	1821356..1821499	-	144	WP_001549059.1	transposase	-
GQX63_RS08650	1821702..1821797	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1821825..1821884	-	60	-	-	Antitoxin
GQX63_RS08655	1821920..1822021	+	102	WP_001791893.1	hypothetical protein	-
GQX63_RS08660	1821999..1822175	-	177	Protein_1695	transposase	-
GQX63_RS08665	1822369..1822746	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1814812..1897273	82461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T145336 WP_001801861.1 NZ_CP047021:1821702-1821797 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T145336 NZ_CP062360:c852877-852689 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCAAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT145336 NZ_CP047021:c1821884-1821825 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin