Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3750937..3751630 Replicon chromosome
Accession NZ_CP047010
Organism Escherichia coli strain 19-5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GQF95_RS18205 Protein ID WP_000415584.1
Coordinates 3751334..3751630 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GQF95_RS18200 Protein ID WP_000650107.1
Coordinates 3750937..3751332 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF95_RS18190 (3746801) 3746801..3749059 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
GQF95_RS18195 (3749197) 3749197..3750804 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GQF95_RS18200 (3750937) 3750937..3751332 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GQF95_RS18205 (3751334) 3751334..3751630 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GQF95_RS18210 (3751835) 3751835..3752317 - 483 WP_000183505.1 GyrI-like domain-containing protein -
GQF95_RS18215 (3752370) 3752370..3752762 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GQF95_RS18220 (3752914) 3752914..3753573 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
GQF95_RS18225 (3753570) 3753570..3754919 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
GQF95_RS18230 (3754965) 3754965..3755297 - 333 WP_000917684.1 DUF2645 family protein -
GQF95_RS18235 (3755616) 3755616..3756197 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GQF95_RS18240 (3756228) 3756228..3756542 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T145313 WP_000415584.1 NZ_CP047010:c3751630-3751334 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T145313 NZ_CP062354:2659475-2659837 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT145313 WP_000650107.1 NZ_CP047010:c3751332-3750937 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT145313 NZ_CP062354:2659308-2659478 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References