Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2733089..2733591 | Replicon | chromosome |
| Accession | NZ_CP047010 | ||
| Organism | Escherichia coli strain 19-5 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | GQF95_RS13505 | Protein ID | WP_000767829.1 |
| Coordinates | 2733089..2733343 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | GQF95_RS13510 | Protein ID | WP_001259255.1 |
| Coordinates | 2733340..2733591 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF95_RS13475 (2728105) | 2728105..2728332 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| GQF95_RS13480 (2728346) | 2728346..2729404 | - | 1059 | WP_053908457.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| GQF95_RS13485 (2729583) | 2729583..2730941 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| GQF95_RS13490 (2730931) | 2730931..2730993 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| GQF95_RS13495 (2731208) | 2731208..2732136 | - | 929 | Protein_2658 | LysR substrate-binding domain-containing protein | - |
| GQF95_RS13500 (2732182) | 2732182..2733006 | - | 825 | WP_000754752.1 | SDR family oxidoreductase | - |
| GQF95_RS13505 (2733089) | 2733089..2733343 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| GQF95_RS13510 (2733340) | 2733340..2733591 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| GQF95_RS13515 (2733875) | 2733875..2733925 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| GQF95_RS13520 (2734071) | 2734071..2734970 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| GQF95_RS13525 (2734976) | 2734976..2736280 | + | 1305 | WP_053908451.1 | histidinol dehydrogenase | - |
| GQF95_RS13530 (2736277) | 2736277..2737347 | + | 1071 | WP_053908449.1 | histidinol-phosphate transaminase | - |
| GQF95_RS13535 (2737347) | 2737347..2738414 | + | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T145308 WP_000767829.1 NZ_CP047010:c2733343-2733089 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T145308 NZ_CP062354:2273267-2273533 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT145308 WP_001259255.1 NZ_CP047010:c2733591-2733340 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT145308 NZ_CP062354:2273010-2273267 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|