Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 90916..91342 | Replicon | plasmid pTEM |
| Accession | NZ_CP047003 | ||
| Organism | Escherichia coli strain J-8 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | GQF94_RS23470 | Protein ID | WP_001372321.1 |
| Coordinates | 90916..91041 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 91118..91342 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF94_RS23440 (86077) | 86077..86619 | - | 543 | WP_000587837.1 | AAA family ATPase | - |
| GQF94_RS23445 (86632) | 86632..87492 | - | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| GQF94_RS23450 (87635) | 87635..88540 | + | 906 | Protein_92 | IS4-like element ISVsa5 family transposase | - |
| GQF94_RS23455 (88589) | 88589..89293 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| GQF94_RS23460 (89357) | 89357..89590 | - | 234 | Protein_94 | DUF932 domain-containing protein | - |
| GQF94_RS23465 (89708) | 89708..89995 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| GQF94_RS25445 (90020) | 90020..90226 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| GQF94_RS25450 (90296) | 90296..90468 | + | 173 | Protein_97 | hypothetical protein | - |
| GQF94_RS25455 (90466) | 90466..90696 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| GQF94_RS23470 (90916) | 90916..91041 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| GQF94_RS25460 (90983) | 90983..91132 | - | 150 | Protein_100 | plasmid maintenance protein Mok | - |
| - (91118) | 91118..91342 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (91118) | 91118..91342 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (91118) | 91118..91342 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (91118) | 91118..91342 | - | 225 | NuclAT_0 | - | Antitoxin |
| GQF94_RS23475 (91154) | 91154..91342 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| GQF94_RS23480 (91311) | 91311..92073 | - | 763 | Protein_102 | plasmid SOS inhibition protein A | - |
| GQF94_RS23485 (92070) | 92070..92504 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| GQF94_RS23490 (92559) | 92559..92756 | - | 198 | Protein_104 | hypothetical protein | - |
| GQF94_RS23495 (92784) | 92784..93017 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| GQF94_RS23500 (93085) | 93085..93624 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| GQF94_RS23505 (93650) | 93650..93856 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| GQF94_RS25465 (93926) | 93926..94006 | + | 81 | Protein_108 | hypothetical protein | - |
| GQF94_RS25470 (94189) | 94189..94358 | - | 170 | Protein_109 | hypothetical protein | - |
| GQF94_RS23510 (94952) | 94952..95923 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1B / oqxA / oqxB / dfrA12 / aadA2 / aph(3')-Ia / mph(A) / aac(3)-IId / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..116304 | 116304 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T145282 WP_001372321.1 NZ_CP047003:c91041-90916 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T145282 NZ_CP062348:2884562-2884813 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATAGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACATATATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
ATGAATAACCGCGAACAAATAGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACATATATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
Antitoxin
Download Length: 225 bp
>AT145282 NZ_CP047003:c91342-91118 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
