Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5138821..5139386 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name higB Uniprot ID I4ITK5
Locus tag GQR42_RS25500 Protein ID WP_002803252.1
Coordinates 5138821..5139099 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQR42_RS25505 Protein ID WP_002767514.1
Coordinates 5139099..5139386 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR42_RS25485 5135285..5135617 + 333 WP_158202108.1 DUF433 domain-containing protein -
GQR42_RS28040 5135851..5135988 + 138 WP_199273243.1 hypothetical protein -
GQR42_RS28045 5136043..5136294 + 252 WP_199273244.1 hypothetical protein -
GQR42_RS25495 5136317..5138509 + 2193 WP_158202109.1 NACHT domain-containing protein -
GQR42_RS25500 5138821..5139099 + 279 WP_002803252.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQR42_RS25505 5139099..5139386 + 288 WP_002767514.1 HigA family addiction module antidote protein Antitoxin
GQR42_RS25510 5139890..5140768 - 879 WP_158202110.1 UDP-N-acetylmuramate dehydrogenase -
GQR42_RS25515 5141104..5142531 - 1428 WP_158202111.1 UDP-N-acetylmuramate--L-alanine ligase -
GQR42_RS25520 5142946..5143962 + 1017 WP_158202112.1 type I glyceraldehyde-3-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10369.79 Da        Isoelectric Point: 8.0988

>T145252 WP_002803252.1 NZ_CP046973:5138821-5139099 [Microcystis aeruginosa FD4]
MIVSFKHRGLEQFFESGTTRGIQANHAKRIRLILARLSAATSPQDMNLPGLVLHELAGQRKGTWTVRVSGNWRITFTFDG
VDACDVDLEDYH

Download         Length: 279 bp

>T145252 NZ_CP062344:c181048-180953 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10511.20 Da        Isoelectric Point: 7.1657

>AT145252 WP_002767514.1 NZ_CP046973:5139099-5139386 [Microcystis aeruginosa FD4]
MKMHNPPHPGEVLKELCLEPLNLTVTEAAEALGVSRKTLSAILNGRAGISPEMAIRLGKAFDTSPESWLNQQMQYDLWQA
EQTIGNIKVKRLSVV

Download         Length: 288 bp

>AT145252 NZ_CP062344:180868-180925 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857DB49

Antitoxin

Source ID Structure

References