Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5138821..5139386 Replicon chromosome
Accession NZ_CP046973
Organism Microcystis aeruginosa FD4

Toxin (Protein)


Gene name higB Uniprot ID I4ITK5
Locus tag GQR42_RS25500 Protein ID WP_002803252.1
Coordinates 5138821..5139099 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQR42_RS25505 Protein ID WP_002767514.1
Coordinates 5139099..5139386 (+) Length 96 a.a.

Genomic Context

GQR42_RS25485GQR42_RS28040GQR42_RS28045GQR42_RS25495GQR42_RS25500GQR42_RS25505GQR42_RS25520GQR42_RS25510GQR42_RS25515
Location: 5135285..5135617 (333 bp)
Type: Others
Protein ID: WP_158202108.1
Location: 5135851..5135988 (138 bp)
Type: Others
Protein ID: WP_199273243.1
Location: 5136043..5136294 (252 bp)
Type: Others
Protein ID: WP_199273244.1
Location: 5136317..5138509 (2193 bp)
Type: Others
Protein ID: WP_158202109.1
Location: 5138821..5139099 (279 bp)
Type: Toxin
Protein ID: WP_002803252.1
Location: 5139099..5139386 (288 bp)
Type: Antitoxin
Protein ID: WP_002767514.1
Location: 5142946..5143962 (1017 bp)
Type: Others
Protein ID: WP_158202112.1
Location: 5139890..5140768 (879 bp)
Type: Others
Protein ID: WP_158202110.1
Location: 5141104..5142531 (1428 bp)
Type: Others
Protein ID: WP_158202111.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQR42_RS254855135285..5135617+333WP_158202108.1DUF433 domain-containing protein-
GQR42_RS280405135851..5135988+138WP_199273243.1hypothetical protein-
GQR42_RS280455136043..5136294+252WP_199273244.1hypothetical protein-
GQR42_RS254955136317..5138509+2193WP_158202109.1NACHT domain-containing protein-
GQR42_RS255005138821..5139099+279WP_002803252.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GQR42_RS255055139099..5139386+288WP_002767514.1HigA family addiction module antidote proteinAntitoxin
GQR42_RS255105139890..5140768-879WP_158202110.1UDP-N-acetylmuramate dehydrogenase-
GQR42_RS255155141104..5142531-1428WP_158202111.1UDP-N-acetylmuramate--L-alanine ligase-
GQR42_RS255205142946..5143962+1017WP_158202112.1type I glyceraldehyde-3-phosphate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10369.79 Da        Isoelectric Point: 8.0988

>T145252 WP_002803252.1 NZ_CP046973:5138821-5139099 [Microcystis aeruginosa FD4]
MIVSFKHRGLEQFFESGTTRGIQANHAKRIRLILARLSAATSPQDMNLPGLVLHELAGQRKGTWTVRVSGNWRITFTFDG
VDACDVDLEDYH

Download         Length: 279 bp

>T145252 NZ_CP062344:c181048-180953 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10511.20 Da        Isoelectric Point: 7.1657

>AT145252 WP_002767514.1 NZ_CP046973:5139099-5139386 [Microcystis aeruginosa FD4]
MKMHNPPHPGEVLKELCLEPLNLTVTEAAEALGVSRKTLSAILNGRAGISPEMAIRLGKAFDTSPESWLNQQMQYDLWQA
EQTIGNIKVKRLSVV

Download         Length: 288 bp

>AT145252 NZ_CP062344:180868-180925 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A857DB49

Antitoxin

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Source
ID
Structure
No matching records found

References