Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 151737..151990 | Replicon | plasmid pKPC2_020130 |
| Accession | NZ_CP046963 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020130 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | CLQ86_RS27955 | Protein ID | WP_001312851.1 |
| Coordinates | 151841..151990 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 151737..151796 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CLQ86_RS27915 (147397) | 147397..147462 | - | 66 | Protein_188 | helix-turn-helix domain-containing protein | - |
| CLQ86_RS27920 (147515) | 147515..148219 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| CLQ86_RS27925 (148244) | 148244..148444 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| CLQ86_RS27930 (148464) | 148464..149210 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| CLQ86_RS27935 (149265) | 149265..149825 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| CLQ86_RS27940 (149957) | 149957..150157 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| CLQ86_RS27945 (150543) | 150543..151142 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| CLQ86_RS27950 (151204) | 151204..151536 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (151737) | 151737..151796 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (151737) | 151737..151796 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (151737) | 151737..151796 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (151737) | 151737..151796 | - | 60 | NuclAT_1 | - | Antitoxin |
| CLQ86_RS27955 (151841) | 151841..151990 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| CLQ86_RS27960 (152274) | 152274..152522 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB | - | 1..152833 | 152833 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T145243 WP_001312851.1 NZ_CP046963:151841-151990 [Klebsiella pneumoniae subsp. pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T145243 NZ_CP062342:1198768-1198956 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 60 bp
>AT145243 NZ_CP046963:c151796-151737 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
