Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1168152..1168803 Replicon chromosome
Accession NZ_CP046909
Organism Paraburkholderia acidiphila strain 7Q-K02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FAZ97_RS05250 Protein ID WP_158757498.1
Coordinates 1168477..1168803 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FAZ97_RS05245 Protein ID WP_158757497.1
Coordinates 1168152..1168484 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ97_RS05220 1163281..1164294 + 1014 WP_199272078.1 phenylalanine--tRNA ligase subunit alpha -
FAZ97_RS05225 1164403..1166859 + 2457 WP_158757495.1 phenylalanine--tRNA ligase subunit beta -
FAZ97_RS05230 1166951..1167361 + 411 WP_028204248.1 integration host factor subunit alpha -
FAZ97_RS05235 1167489..1167887 + 399 WP_158757496.1 MerR family transcriptional regulator -
FAZ97_RS05245 1168152..1168484 - 333 WP_158757497.1 helix-turn-helix domain-containing protein Antitoxin
FAZ97_RS05250 1168477..1168803 - 327 WP_158757498.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FAZ97_RS05255 1169094..1170032 + 939 WP_158757499.1 DMT family transporter -
FAZ97_RS05260 1170163..1171557 - 1395 WP_158757500.1 MFS transporter -
FAZ97_RS05265 1172193..1172762 + 570 WP_158757501.1 acyloxyacyl hydrolase -
FAZ97_RS05270 1172876..1173208 + 333 WP_158757502.1 DUF190 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-105)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12287.24 Da        Isoelectric Point: 10.4304

>T145144 WP_158757498.1 NZ_CP046909:c1168803-1168477 [Paraburkholderia acidiphila]
MWTITYYNEATRQQVAHLPTGILASYLRLANAMQSHGADLRMPHSRAMCGGLFELRPRGPEGIGRVFYCTQVGRRIVVLH
SFVKKTRETPEAELSLARKRMKEVQENG

Download         Length: 327 bp

>T145144 NZ_CP062320:c1872130-1872026 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11893.68 Da        Isoelectric Point: 9.5068

>AT145144 WP_158757497.1 NZ_CP046909:c1168484-1168152 [Paraburkholderia acidiphila]
MAKSRPKREGVEQYKPVPHDEAFVKAMLAKPEVKAAYDALDEEFSALDVLLSARKEAGLTQAQVAERMGTTTSAVSRLEA
SLASEKHSPSFATLRKYAAACGKSLRIALV

Download         Length: 333 bp

>AT145144 NZ_CP062320:1871932-1871970 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References