Detailed information of TA system TA145141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 126861..127438
• Replicon: chromosome
• Accession: NZ_CP046908
• Organism: Stappia indica strain PHM037

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GH266_RS00645
• Protein ID: WP_158192170.1
• Coordinates: 127160..127438 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GH266_RS00640
• Protein ID: WP_158192169.1
• Coordinates: 126861..127148 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH266_RS00620	122717..123805	+	1089	WP_209001516.1	polysaccharide deacetylase family protein	-
GH266_RS00625	123780..124010	-	231	WP_209001517.1	DUF2842 domain-containing protein	-
GH266_RS00630	124221..125324	+	1104	WP_158192167.1	COX15/CtaA family protein	-
GH266_RS00635	125397..126680	-	1284	WP_158192168.1	O-acetylhomoserine aminocarboxypropyltransferase	-
GH266_RS00640	126861..127148	-	288	WP_158192169.1	HigA family addiction module antidote protein	Antitoxin
GH266_RS00645	127160..127438	-	279	WP_158192170.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH266_RS00650	127518..127973	-	456	WP_158195978.1	CoA-binding protein	-
GH266_RS00655	128056..128886	-	831	WP_158192171.1	enoyl-CoA hydratase	-
GH266_RS00660	129048..129461	+	414	WP_158195979.1	PaaI family thioesterase	-
GH266_RS00665	129690..130157	+	468	WP_067214860.1	50S ribosomal protein L13	-
GH266_RS00670	130161..130637	+	477	WP_120268038.1	30S ribosomal protein S9	-
GH266_RS00675	130701..131123	-	423	WP_067333342.1	Lrp/AsnC family transcriptional regulator	-
GH266_RS00680	131312..132265	+	954	WP_158192172.1	arginase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (2-93)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10619.32 Da
• Isoelectric Point: 10.3755

>T145141 WP_158192170.1 NZ_CP046908:c127438-127160 [Stappia indica]
MIKSFKDERARIIFQGNVPKKFPTEILRIAQRKIAMLNAAISLVDLRIPPGNRLEALKGNRAGQHSIRINDQYRICFIWN
DGAENVEITDYH

Nucleotide

• Length: 279 bp

>T145141 NZ_CP062320:c1697542-1697366 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10863.41 Da
• Isoelectric Point: 4.5173

>AT145141 WP_158192169.1 NZ_CP046908:c127148-126861 [Stappia indica]
MLAPVHPGEILREEFLSEYGLSPYALAKALGVPRTRLERIVREETPVTIDTAMRLSRFFGTSAEFWLNLQTQFDLQTARE
TLADEIEQIRPLETA

Nucleotide

• Length: 288 bp

>AT145141 NZ_CP062320:1697243-1697302 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTA