Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3341696..3342408 Replicon chromosome
Accession NZ_CP046907
Organism Streptomyces sp. SCUT-3

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag GQS52_RS14730 Protein ID WP_182313878.1
Coordinates 3341696..3342058 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQS52_RS14735 Protein ID WP_182313879.1
Coordinates 3342055..3342408 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQS52_RS14710 3337155..3338285 - 1131 WP_182313875.1 methyltransferase domain-containing protein -
GQS52_RS14715 3338282..3338461 - 180 WP_182313876.1 hypothetical protein -
GQS52_RS14720 3338916..3339923 + 1008 WP_182316458.1 polyprenyl synthetase family protein -
GQS52_RS14725 3340214..3341554 + 1341 WP_182313877.1 DUF2092 domain-containing protein -
GQS52_RS14730 3341696..3342058 + 363 WP_182313878.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQS52_RS14735 3342055..3342408 + 354 WP_182313879.1 XRE family transcriptional regulator Antitoxin
GQS52_RS14740 3342688..3344451 + 1764 WP_182313880.1 ATP-binding cassette domain-containing protein -
GQS52_RS14745 3344561..3345466 + 906 WP_182313881.1 virginiamycin B lyase -
GQS52_RS14750 3345559..3346563 - 1005 WP_182313882.1 EamA family transporter RarD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13615.40 Da        Isoelectric Point: 5.6770

>T145140 WP_182313878.1 NZ_CP046907:3341696-3342058 [Streptomyces sp. SCUT-3]
MSWEIILTSEVHDWFLGLSDPSASLVRDSVELLARQGPALGRPAVDRIHGSQLHNLKELRPGSSGRSEIRILFVFDPTRR
AILLVAGDKAGNWQSWYTEAVKLAEERYARYLDSRPEEIE

Download         Length: 363 bp

>T145140 NZ_CP062320:c1594314-1594162 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 12799.44 Da        Isoelectric Point: 7.3187

>AT145140 WP_182313879.1 NZ_CP046907:3342055-3342408 [Streptomyces sp. SCUT-3]
MSKHYRWQTTLDARRAADPGIDAPERIAAARETREKAVLGHLLGELRKERGLTQADVAAAMGVSQVRVSRMENGEIDRMQ
VDSIASYIAALGGHLRLVADFGPTSTTFADYTDRLSA

Download         Length: 354 bp

>AT145140 NZ_CP062320:c1594938-1594339 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References