Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2662342..2662925 Replicon chromosome
Accession NZ_CP046907
Organism Streptomyces sp. SCUT-3

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag GQS52_RS11740 Protein ID WP_182313352.1
Coordinates 2662656..2662925 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQS52_RS11735 Protein ID WP_182313351.1
Coordinates 2662342..2662659 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQS52_RS11710 2658931..2660142 - 1212 WP_182313338.1 pyridoxal phosphate-dependent aminotransferase -
GQS52_RS11715 2660224..2660874 + 651 WP_182313339.1 helix-turn-helix transcriptional regulator -
GQS52_RS11720 2661000..2661356 + 357 WP_182313340.1 MmcQ/YjbR family DNA-binding protein -
GQS52_RS11725 2661546..2661980 - 435 WP_182313349.1 PIN domain-containing protein -
GQS52_RS11730 2661977..2662216 - 240 WP_182313350.1 ribbon-helix-helix domain-containing protein -
GQS52_RS11735 2662342..2662659 - 318 WP_182313351.1 helix-turn-helix transcriptional regulator Antitoxin
GQS52_RS11740 2662656..2662925 - 270 WP_182313352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQS52_RS11745 2663080..2663829 - 750 WP_182313353.1 LUD domain-containing protein -
GQS52_RS11750 2663826..2665346 - 1521 WP_182313354.1 iron-sulfur cluster-binding protein -
GQS52_RS11755 2665343..2666104 - 762 WP_182313355.1 (Fe-S)-binding protein -
GQS52_RS11760 2666148..2667782 - 1635 WP_182313357.1 L-lactate permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-73)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-92)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9897.35 Da        Isoelectric Point: 8.3538

>T145139 WP_182313352.1 NZ_CP046907:c2662925-2662656 [Streptomyces sp. SCUT-3]
MCAYCEGACCALASGAALHNLKELRPGSCGNSEIRILFAFDPQRSAVLLVAGDKAGQWTEWYRRAIPLAETRYGEWLDHL
AQRQKGTRK

Download         Length: 270 bp

>T145139 NZ_CP062320:1536315-1536410 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11527.06 Da        Isoelectric Point: 6.2309

>AT145139 WP_182313351.1 NZ_CP046907:c2662659-2662342 [Streptomyces sp. SCUT-3]
MTTFHSWDEAKHEIFDSEDLDDIRAGARRMVAEARAHRLAEMRKQLGLTQSDVAARMQVRQERVSAIERGRTTTAEVGTI
AAYIAALGGTLEIVADFGGVRVVVA

Download         Length: 318 bp

>AT145139 NZ_CP062320:c1536497-1536438 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References