Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 97399..97984 Replicon plasmid pA1429c
Accession NZ_CP046899
Organism Acinetobacter baumannii strain A1429

Toxin (Protein)


Gene name higB Uniprot ID A0A7S7BY50
Locus tag GQO96_RS19445 Protein ID WP_000897311.1
Coordinates 97664..97984 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQO96_RS19440 Protein ID WP_000369784.1
Coordinates 97399..97671 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQO96_RS19410 92885..93457 + 573 WP_000960976.1 aminoglycoside N-acetyltransferase AAC(6')-Ian -
GQO96_RS19415 93409..93606 - 198 Protein_93 ATP-dependent DNA helicase RecG -
GQO96_RS19420 94114..95643 + 1530 WP_000093022.1 IS91 family transposase -
GQO96_RS19425 95789..95968 + 180 Protein_95 IS6 family transposase -
GQO96_RS19430 96019..96723 - 705 WP_001067790.1 IS6-like element IS1008 family transposase -
GQO96_RS19435 96788..97366 - 579 Protein_97 DUF2971 domain-containing protein -
GQO96_RS19440 97399..97671 - 273 WP_000369784.1 helix-turn-helix domain-containing protein Antitoxin
GQO96_RS19445 97664..97984 - 321 WP_000897311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQO96_RS19450 98663..99595 - 933 WP_000743272.1 IS5-like element IS17 family transposase -
GQO96_RS19455 99649..100086 + 438 Protein_101 IS3 family transposase -
GQO96_RS19460 100344..101576 + 1233 WP_001255535.1 ATP-binding protein -
GQO96_RS19465 101848..102177 - 330 WP_000506885.1 DUF4236 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / aac(3)-IIa / aac(6')-Ian / aph(3'')-Ib / aph(6)-Id / tet(B) / sul2 - 1..205113 205113
- inside IScluster/Tn blaTEM-1B / aac(3)-IIa / aac(6')-Ian - 85281..100086 14805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-84)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12214.03 Da        Isoelectric Point: 7.9500

>T145131 WP_000897311.1 NZ_CP046899:c97984-97664 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG

Download         Length: 321 bp

>T145131 NZ_CP062318:2296821-2296928 [Staphylococcus aureus]
ATCTTCAATTTATTAATTGACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCAAATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10145.57 Da        Isoelectric Point: 7.0146

>AT145131 WP_000369784.1 NZ_CP046899:c97671-97399 [Acinetobacter baumannii]
MDNNLFDDLVTSIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI

Download         Length: 273 bp

>AT145131 NZ_CP062318:c2297005-2296945 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S7BY50

Antitoxin

Source ID Structure

References