Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
Location | 97399..97984 | Replicon | plasmid pA1429c |
Accession | NZ_CP046899 | ||
Organism | Acinetobacter baumannii strain A1429 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7S7BY50 |
Locus tag | GQO96_RS19445 | Protein ID | WP_000897311.1 |
Coordinates | 97664..97984 (-) | Length | 107 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GQO96_RS19440 | Protein ID | WP_000369784.1 |
Coordinates | 97399..97671 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GQO96_RS19410 | 92885..93457 | + | 573 | WP_000960976.1 | aminoglycoside N-acetyltransferase AAC(6')-Ian | - |
GQO96_RS19415 | 93409..93606 | - | 198 | Protein_93 | ATP-dependent DNA helicase RecG | - |
GQO96_RS19420 | 94114..95643 | + | 1530 | WP_000093022.1 | IS91 family transposase | - |
GQO96_RS19425 | 95789..95968 | + | 180 | Protein_95 | IS6 family transposase | - |
GQO96_RS19430 | 96019..96723 | - | 705 | WP_001067790.1 | IS6-like element IS1008 family transposase | - |
GQO96_RS19435 | 96788..97366 | - | 579 | Protein_97 | DUF2971 domain-containing protein | - |
GQO96_RS19440 | 97399..97671 | - | 273 | WP_000369784.1 | helix-turn-helix domain-containing protein | Antitoxin |
GQO96_RS19445 | 97664..97984 | - | 321 | WP_000897311.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GQO96_RS19450 | 98663..99595 | - | 933 | WP_000743272.1 | IS5-like element IS17 family transposase | - |
GQO96_RS19455 | 99649..100086 | + | 438 | Protein_101 | IS3 family transposase | - |
GQO96_RS19460 | 100344..101576 | + | 1233 | WP_001255535.1 | ATP-binding protein | - |
GQO96_RS19465 | 101848..102177 | - | 330 | WP_000506885.1 | DUF4236 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaTEM-1B / aac(3)-IIa / aac(6')-Ian / aph(3'')-Ib / aph(6)-Id / tet(B) / sul2 | - | 1..205113 | 205113 | |
- | inside | IScluster/Tn | blaTEM-1B / aac(3)-IIa / aac(6')-Ian | - | 85281..100086 | 14805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12214.03 Da Isoelectric Point: 7.9500
>T145131 WP_000897311.1 NZ_CP046899:c97984-97664 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG
Download Length: 321 bp
>T145131 NZ_CP062318:2296821-2296928 [Staphylococcus aureus]
ATCTTCAATTTATTAATTGACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCAAATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA
ATCTTCAATTTATTAATTGACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCAAATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10145.57 Da Isoelectric Point: 7.0146
>AT145131 WP_000369784.1 NZ_CP046899:c97671-97399 [Acinetobacter baumannii]
MDNNLFDDLVTSIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI
MDNNLFDDLVTSIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI
Download Length: 273 bp
>AT145131 NZ_CP062318:c2297005-2296945 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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