Detailed information of TA system TA145126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1884147..1884720
• Replicon: chromosome
• Accession: NZ_CP046884
• Organism: Corynebacterium sp. 4H37-19

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GP475_RS08855
• Protein ID: WP_187974046.1
• Coordinates: 1884147..1884428 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GP475_RS08860
• Protein ID: WP_187974047.1
• Coordinates: 1884415..1884720 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GP475_RS08835	1879485..1880843	-	1359	WP_187974042.1	phage portal protein	-
GP475_RS08840	1881184..1881717	-	534	WP_187974043.1	hypothetical protein	-
GP475_RS08845	1881714..1882088	-	375	WP_187974044.1	hypothetical protein	-
GP475_RS08850	1883619..1883990	+	372	WP_187974045.1	transcriptional regulator	-
GP475_RS08855	1884147..1884428	+	282	WP_187974046.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GP475_RS08860	1884415..1884720	+	306	WP_187974047.1	HigA family addiction module antidote protein	Antitoxin
GP475_RS08865	1884738..1885169	-	432	WP_187974048.1	hypothetical protein	-
GP475_RS08870	1885230..1885592	-	363	WP_187974049.1	hypothetical protein	-
GP475_RS08875	1885706..1886593	-	888	WP_187974050.1	hypothetical protein	-
GP475_RS08880	1886596..1886895	-	300	WP_187974051.1	hypothetical protein	-
GP475_RS08885	1886925..1887368	-	444	WP_187974052.1	single-stranded DNA-binding protein	-
GP475_RS08890	1887365..1888201	-	837	WP_187974053.1	hypothetical protein	-
GP475_RS08895	1888212..1889138	-	927	WP_187974054.1	YqaJ viral recombinase family protein	-
GP475_RS08900	1889135..1889314	-	180	WP_187974055.1	hypothetical protein	-
GP475_RS08905	1889383..1889625	-	243	WP_187974056.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1863212..1898022	34810

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10909.48 Da
• Isoelectric Point: 10.3381

>T145126 WP_187974046.1 NZ_CP046884:1884147-1884428 [Corynebacterium sp. 4H37-19]
VIESFKGKIAPQIWNREAPKKFDSRLHRRTYIKLVSIHQARSLQDIALTPGTNLEALKGDRKGQYSIRINSQWRICFTWE
DGKAREVEVVDYH

Nucleotide

• Length: 282 bp

>T145126 NZ_CP062318:18899-19075 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11411.24 Da
• Isoelectric Point: 6.7186

>AT145126 WP_187974047.1 NZ_CP046884:1884415-1884720 [Corynebacterium sp. 4H37-19]
MTTTKMPPVHPGEVLVQEFLEPLGMTQHKLAVRIGVPPRRVNEIVHGKRGISADTAVRLQRFFGVSAEYWMGLQSQYELM
CAEDRMEEAVEKIVPFSDRAA

Nucleotide

• Length: 306 bp

>AT145126 NZ_CP062318:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG