Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4090082..4090782 Replicon chromosome
Accession NZ_CP046872
Organism Pseudomonas putida strain MX-2

Toxin (Protein)


Gene name mqsR Uniprot ID A0A2I0CDW7
Locus tag GPM17_RS18665 Protein ID WP_003254238.1
Coordinates 4090486..4090782 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID I7AUJ7
Locus tag GPM17_RS18660 Protein ID WP_003254235.1
Coordinates 4090082..4090483 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPM17_RS18640 4085216..4086037 - 822 WP_003254229.1 transporter substrate-binding domain-containing protein -
GPM17_RS18645 4086113..4087042 - 930 WP_070096583.1 FAD-binding protein -
GPM17_RS18650 4087043..4087792 - 750 WP_003254232.1 electron transfer flavoprotein subunit beta/FixA family protein -
GPM17_RS18655 4088328..4090010 + 1683 WP_010954959.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
GPM17_RS18660 4090082..4090483 - 402 WP_003254235.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
GPM17_RS18665 4090486..4090782 - 297 WP_003254238.1 type II toxin-antitoxin system MqsR family toxin Toxin
GPM17_RS18670 4090877..4092202 - 1326 WP_004573659.1 MFS transporter -
GPM17_RS18675 4092275..4092754 - 480 WP_003254240.1 hypothetical protein -
GPM17_RS18680 4092923..4093399 - 477 WP_003254241.1 sigma-70 family RNA polymerase sigma factor -
GPM17_RS18685 4093521..4095146 - 1626 WP_098091125.1 PvdJ/PvdD/PvdP-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11110.18 Da        Isoelectric Point: 10.2270

>T145118 WP_003254238.1 NZ_CP046872:c4090782-4090486 [Pseudomonas putida]
MEKRMPNCPLERVKALAAARRIRPTGAALKGAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVWQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKEL

Download         Length: 297 bp

>T145118 NZ_CP062314:c180120-180025 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14684.76 Da        Isoelectric Point: 4.9531

>AT145118 WP_003254235.1 NZ_CP046872:c4090483-4090082 [Pseudomonas putida]
MRCPICGGSELAPDIQGMPYSYKGEMTVIPEVSGDYCSACGECVLSHDEAMRVSHLMTAFERQVNANVVDPSFIASIRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp

>AT145118 NZ_CP062314:179938-179997 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I0CDW7

Antitoxin

Source ID Structure
AlphaFold DB I7AUJ7

References