Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 37799..38432 Replicon chromosome
Accession NZ_CP046849
Organism Vibrio cincinnatiensis strain F8054

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GPX94_RS13160 Protein ID WP_000843587.1
Coordinates 37799..38131 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GPX94_RS13165 Protein ID WP_000071008.1
Coordinates 38118..38432 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX94_RS13125 34496..34891 + 396 WP_154116906.1 hypothetical protein -
GPX94_RS13130 34888..35004 + 117 Protein_50 DUF3265 domain-containing protein -
GPX94_RS13135 35051..35410 + 360 WP_154116316.1 hypothetical protein -
GPX94_RS13140 35560..36867 + 1308 WP_154116314.1 DUF3644 domain-containing protein -
GPX94_RS13145 37047..37217 + 171 WP_001080654.1 hypothetical protein -
GPX94_RS13150 37217..37618 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPX94_RS13155 37588..37731 + 144 WP_195707336.1 DUF3265 domain-containing protein -
GPX94_RS13160 37799..38131 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPX94_RS13165 38118..38432 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
GPX94_RS13170 39219..39515 + 297 WP_053339486.1 PQQ-binding-like beta-propeller repeat protein -
GPX94_RS13175 40322..41446 + 1125 WP_154116312.1 ISAs1 family transposase -
GPX94_RS13180 41518..41982 + 465 WP_154116310.1 hypothetical protein -
GPX94_RS13185 42114..42548 + 435 WP_154116308.1 hypothetical protein -
GPX94_RS13190 42739..42960 + 222 Protein_62 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / katB 1..1034285 1034284
- flank IS/Tn - - 32088..33044 956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145098 WP_000843587.1 NZ_CP046849:37799-38131 [Vibrio cincinnatiensis]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145098 NZ_CP062265:1815094-1815435 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145098 WP_000071008.1 NZ_CP046849:38118-38432 [Vibrio cincinnatiensis]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145098 NZ_CP062265:1814864-1815094 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References