Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 64377..64992 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | GPY04_RS14585 | Protein ID | WP_001162670.1 |
| Coordinates | 64705..64992 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPY04_RS14580 | Protein ID | WP_001232701.1 |
| Coordinates | 64377..64694 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14535 | 59469..59924 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14540 | 60054..60929 | - | 876 | WP_000259044.1 | hypothetical protein | - |
| GPY04_RS14550 | 61376..61858 | - | 483 | WP_001895003.1 | hypothetical protein | - |
| GPY04_RS14555 | 61915..62745 | - | 831 | WP_000056616.1 | abortive infection family protein | - |
| GPY04_RS14560 | 62950..63690 | - | 741 | WP_000469836.1 | PhzF family phenazine biosynthesis protein | - |
| GPY04_RS14565 | 63914..63952 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| GPY04_RS14570 | 63968..64093 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| GPY04_RS19380 | 64270..64380 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14580 | 64377..64694 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| GPY04_RS14585 | 64705..64992 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY04_RS14590 | 65259..65439 | - | 181 | Protein_115 | DUF645 family protein | - |
| GPY04_RS14595 | 65864..66097 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| GPY04_RS14600 | 66500..66718 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| GPY04_RS14605 | 67028..67681 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| GPY04_RS14610 | 67738..68247 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14615 | 68489..68731 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY04_RS14620 | 68750..69067 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY04_RS19385 | 69261..69356 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T145084 WP_001162670.1 NZ_CP046845:c64992-64705 [Vibrio cholerae C6706]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T145084 NZ_CP062254:3396476-3396679 [Pectobacterium parmentieri]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACGATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTGGCAGAGTTGACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACGATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTGGCAGAGTTGACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT145084 WP_001232701.1 NZ_CP046845:c64694-64377 [Vibrio cholerae C6706]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT145084 NZ_CP062254:3396052-3396420 [Pectobacterium parmentieri]
ATGGATGAGTACACACCAAAGCATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAGAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACTTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTCTCAGAGCAGGTTGAAAAATATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGACGCTGAACTACGACGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA
ATGGATGAGTACACACCAAAGCATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAGAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACTTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTCTCAGAGCAGGTTGAAAAATATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGACGCTGAACTACGACGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|